tesofensine
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- CAS番号.
- 195875-84-4
- 化学名:
- 别名:
- 英語名:
- tesofensine
- 英語别名:
- Tesofensine-13C-d3;(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;(1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane;8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-
- CBNumber:
- CB12498844
- 化学式:
- C17H23Cl2NO
- 分子量:
- 328.28
- MOL File:
- 195875-84-4.mol
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tesofensine 物理性質
- 沸点 :
- 396.6±42.0 °C(Predicted)
- 比重(密度) :
- 1.161±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMF: 2 mg/mL,DMSO: 1 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.14 mg/mL
- 外見 :
- A solid
- 酸解離定数(Pka):
- 10.46±0.60(Predicted)
- 色:
- White to off-white
- 安定性：:
- Hygroscopic
- InChI:
- InChI=1S/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12-,13+,14+,17+/m0/s1
- InChIKey:
- VCVWXKKWDOJNIT-ZOMKSWQUSA-N
- SMILES:
- [C@@]12([H])N(C)[C@@]([H])(CC1)C[C@H](C1=CC=C(Cl)C(Cl)=C1)[C@H]2COCC
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
tesofensine 価格
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製品番号 |
製品説明 |
CAS番号 |
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tesofensine 化学特性,用途語,生産方法
来歴
Tesofensine is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed by NeuroSearch for the treatment of Alzheimer's disease and Parkinson's disease. Development of the compound for these neurological indications was unsuccessful but significant weight loss was reported during the clinical trials in Parkinson's disease. Hence, tesofensine is now being developed by NeuroSearch for the treatment of obesity and type 2 diabetes[1].
使用
Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is currently in clinical development for the treatment of obesity.
tesofensine 上流と下流の製品情報
原材料
準備製品
tesofensine 生産企業
Global( 37)Suppliers
- 195875-84-4
- (1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
- (1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
- Tesofensine-13C-d3
- 8-Azabicyclo[3.2.1]octane, 3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-, (1R,2R,3S,5S)-