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15-keto-17-phenyl trinor Prostaglandin F2α

15-keto-17-phenyl trinor Prostaglandin F2α Structure
15-keto-17-phenyl trinor Prostaglandin F2α structure
CAS No.
949564-89-0
Chemical Name:
15-keto-17-phenyl trinor Prostaglandin F2α
Synonyms
HHEYLKRDELKWGI-RKJYIPPQSA-N;15-keto-17-phenyl trinor Prostaglandin F2α;15-keto-17-phenyl trinor Prostaglandin F2α;9α,11α-dihydroxy-15-oxo-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oicacid;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl]-, (5Z)-
CBNumber:
CB12589913
Molecular Formula:
C23H30O5
Molecular Weight:
386.48
MDL Number:
MFCD03411997
MOL File:
949564-89-0.mol
Last updated:2024-10-23 13:36:13
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15-keto-17-phenyl trinor Prostaglandin F2α Properties

Boiling point 594.2±50.0 °C(Predicted)
Density 1.216±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2.5 mg/ml
pka 4.76±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H319-H360-H336
Precautionary statements  P201-P202-P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

15-keto-17-phenyl trinor Prostaglandin F2α price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16817 15-keto-17-phenyl trinor Prostaglandin F2α ≥98% 949564-89-0 1mg $64 2024-03-01 Buy
Cayman Chemical 16817 15-keto-17-phenyl trinor Prostaglandin F2α ≥98% 949564-89-0 5mg $280 2024-03-01 Buy
Cayman Chemical 16817 15-keto-17-phenyl trinor Prostaglandin F2α ≥98% 949564-89-0 10mg $497 2024-03-01 Buy
AK Scientific 0676DJ (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoicacid 949564-89-0 10mg $650 2021-12-16 Buy
Product number Packaging Price Buy
16817 1mg $64 Buy
16817 5mg $280 Buy
16817 10mg $497 Buy
0676DJ 10mg $650 Buy

15-keto-17-phenyl trinor Prostaglandin F2α Chemical Properties,Uses,Production

Description

Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.1 Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.2 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye.

References

1. Cantor, L.B. Bimatoprost: a member of a new class of agents, the prostamides, for glaucoma management Expert Opin. Investig. Drugs 10,721-731(2001).
2. Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment Drugs Future 17(8),691-704(1992).

15-keto-17-phenyl trinor Prostaglandin F2α Preparation Products And Raw materials

Raw materials

Preparation Products

15-keto-17-phenyl trinor Prostaglandin F2α Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32038 58
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1990 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19711 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

View Lastest Price from 15-keto-17-phenyl trinor Prostaglandin F2α manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
15-keto-17-phenyl trinor Prostaglandin F2α pictures 2024-10-24 15-keto-17-phenyl trinor Prostaglandin F2α
949564-89-0
 US $160.00-686.00 / mg 10g TargetMol Chemicals Inc.
15-keto-17-phenyl trinor Prostaglandin F2α HHEYLKRDELKWGI-RKJYIPPQSA-N (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid 15-keto-17-phenyl trinor Prostaglandin F2α 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl]-, (5Z)- 9α,11α-dihydroxy-15-oxo-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oicacid 949564-89-0