ELR-510444
- CAS No.
- 1233948-35-0
- Chemical Name:
- ELR-510444
- Synonyms
- CS-1765;LR-510444;ELR-510444;ELR510444, >95%;ELR-510444;ELR510444;N-[5-(5-Cyano-2-thienyl)-2-methylphenyl]-4-methylbenzenesulfonamide;Benzenesulfonamide, N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl-;N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide;N-(5-(5-cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide ELR-510444
- CBNumber:
- CB12627798
- Molecular Formula:
- C19H16N2O2S2
- Molecular Weight:
- 368.47
- MDL Number:
- MFCD25976813
- MOL File:
- 1233948-35-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H314 | |||||||||
Precautionary statements | P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310 | |||||||||
NFPA 704 |
|
ELR-510444 price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 17696 | ELR510444 ≥95% | 1233948-35-0 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 17696 | ELR510444 ≥95% | 1233948-35-0 | 5mg | $161 | 2024-03-01 | Buy |
Cayman Chemical | 17696 | ELR510444 ≥95% | 1233948-35-0 | 10mg | $257 | 2024-03-01 | Buy |
Cayman Chemical | 17696 | ELR510444 ≥95% | 1233948-35-0 | 25mg | $479 | 2024-03-01 | Buy |
AK Scientific | 8445DG | N-(5-(5-Cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide | 1233948-35-0 | 25mg | $631 | 2021-12-16 | Buy |
ELR-510444 Chemical Properties,Uses,Production
Description
ELR510444 is an inhibitor of tubulin polymerization (IC50 = 10 μM) that binds to tubulin at the colchicine binding site. It induces microtubule depolymerization in A-10 cells (EC50 = 21 nM). ELR510444 inhibits growth in a cancer cell line panel (IC50s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest. Oral administration of ELR510444 (3-6 mg/kg) reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner. ELR510444 also inhibits hypoxia-inducible factor 1α (HIF-1α) in RCC4 cells in a concentration-dependent manner.
in vitro
elr510444 has potent microtubuledisrupting activity, causing a loss of intracellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. elr510444 inhibited cell proliferation, inhibited the rate and extent of purified tubulin assembly potently, and displaced colchicine from tubulin, revealing that the drug directly interacts with tubulin at the colchicine-binding site [1].
in vivo
elr510444 also shows potent antitumor activity in the mda-mb-231 xenograft model with at least a 2-fold therapeutic window [1].
References
[1] risinger al, westbrook cd, encinas a, mülbaier m, schultes cm, wawro s, lewis jd, janssen b, giles fj, mooberry sl. elr510444, a novel microtubule disruptor with multiple mechanisms of action. j pharmacol exp ther. 2011 mar;336(3):652-60.
ELR-510444 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from ELR-510444 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-09-06 | N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide
1233948-35-0
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
- N-(5-(5-cyanothiophen-2-yl)-2-Methylphenyl)-4-MethylbenzenesulfonaMide
1233948-35-0
- US $1.00 / KG
- 98%
- Career Henan Chemical Co