AMidepsine D
- CAS No.
- 79786-34-8
- Chemical Name:
- AMidepsine D
- Synonyms
- Amidepsin D;AMidepsine D;2,4-di-O-methylgyrophoric acid;4-[(2,4-Dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-benzoic acid 4-carboxy-3-hydroxy-5-methylphenyl ester;Benzoic acid, 4-[(2,4-dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-, 4-carboxy-3-hydroxy-5-methylphenyl ester
- CBNumber:
- CB12650495
- Molecular Formula:
- C26H24O10
- Molecular Weight:
- 496.46
- MDL Number:
- MFCD28138426
- MOL File:
- 79786-34-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
AMidepsine D price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17775 | Amidepsine D ≥95% | 79786-34-8 | 1mg | $275 | 2024-03-01 | Buy |
| Cayman Chemical | 17775 | Amidepsine D ≥95% | 79786-34-8 | 2.5mg | $547 | 2024-03-01 | Buy |
| TRC | A576700 | AmidepsineD | 79786-34-8 | 10mg | $1230 | 2021-12-16 | Buy |
| Usbiological | 207044 | Amidepsine D | 79786-34-8 | 1mg | $443 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0110-MM25 | AmidepsineD ≥95%(HPLC) | 79786-34-8 | 2.5mg | $470 | 2021-12-16 | Buy |
AMidepsine D Chemical Properties,Uses,Production
Uses
Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp, which inhibits DGAT activity, thus triacylglycerol formation is attenuated and protects against the development of diet-induced obesity or insulin-resistance.
Biological Activity
amidepsine d is a fungal metabolite isolated from the culture broth of humicola sp fo-2942. amidepsine a is an inhibitor of dylglycerol acyltransferase (dgat).dylglycerol acyltransferase (dgat) has been involved in catalyzing the formation of triglycerides from diacylglycerol and acyl-coa. the reaction is considered the terminal and only committed step in triglyceride synthesis and is essential for the formation of adipose tissue. there are two isozymes of dgat have been identified: dgat1 and dgat2. dgat-1 deficient mice are lean and resistant to the development of diet-induced obesity or insulin resistance [1]. dgat2-/- mice demonstrate reduced triglyceride levels and suffer from skin barrier abnormalities [2].fo-2942 inhibited dgat activity with an ic50 of 10.2 μm in rat liver microsomes. fo-2942 inhibited triacylglycerol formation in raji cells with the ic50 value of 15.5 μm [1].
storage
+4°C
References
[1] tomoda h, tabata n, ito m, et al. amidepsines, inhibitors of diacylglycerol acyltransferase produced by humicola sp. fo-2942[j]. the journal of antibiotics, 1995, 48(9): 942-947.
[2] smith s j, cases s, jensen d r, et al. obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking dgat[j]. nature genetics, 2000, 25(1): 87-90.
[3] stone s j, myers h m, watkins s m, et al. lipopenia and skin barrier abnormalities in dgat2-deficient mice[j]. journal of biological chemistry, 2004, 279(12): 11767-11776.
AMidepsine D Preparation Products And Raw materials
AMidepsine D Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Changzhou Extraordinary Pharmatech co., LTD. | +86-519-82111935 15195055733 | info@feifanchem.com | China | 362 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | jiangnan@huidabiotech.com | China | 3656 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | sunshixuan@huidabiotech.com | China | 3705 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |