Ethoxycarbonyl Isothiocyanate
- CAS No.
- 16182-04-0
- Chemical Name:
- Ethoxycarbonyl Isothiocyanate
- Synonyms
- O-ethyl carbonisothiocyanatidate;ethyl N-carbothioylcarbamate;ETHYL ISOTHIOCYANATOFORMATE;Ethyl carbonisothiocyanatidate;NSC 158480;CARBETHOXYISOTHIOCYANATE;Ethoxycarbonyl Mustard Oil;ETHOXYCARBONYL ISOTHIOCYANATE;ETHYL ISOTHIOCYANATOFORMATE,98%;Ethyl isothiocyanatidocarbonate
- CBNumber:
- CB1265381
- Molecular Formula:
- C4H5NO2S
- Molecular Weight:
- 131.15
- MDL Number:
- MFCD00004814
- MOL File:
- 16182-04-0.mol
- MSDS File:
- SDS
| Boiling point | 56 °C18 mm Hg(lit.) |
|---|---|
| Density | 1.112 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 123 °F |
| storage temp. | 2-8°C |
| solubility | Soluble in chloroform and ether. |
| form | Oil |
| color | Light Yellow |
| Specific Gravity | 1.112 |
| Sensitive | Moisture Sensitive/Lachrymatory |
| BRN | 606091 |
| InChIKey | BDTDECDAHYOJRO-UHFFFAOYSA-N |
| CAS DataBase Reference | 16182-04-0(CAS DataBase Reference) |
| FDA UNII | WQY39AV49E |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H315-H317-H319-H331-H334-H335 | |||||||||
| Precautionary statements | P210-P280-P302+P352-P304+P340+P311-P305+P351+P338 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 23-36/37/38-42 | |||||||||
| Safety Statements | 23-26-36/37/39-45 | |||||||||
| RIDADR | UN 2929 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 9-13-19-21 | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29309090 | |||||||||
| NFPA 704 |
|
Ethoxycarbonyl Isothiocyanate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 196126 | Ethoxycarbonyl isothiocyanate 98% | 16182-04-0 | 5g | $89.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 196126 | Ethoxycarbonyl isothiocyanate 98% | 16182-04-0 | 25g | $260 | 2024-03-01 | Buy |
| TCI Chemical | E0440 | Ethoxycarbonyl Isothiocyanate >95.0%(GC) | 16182-04-0 | 5g | $26 | 2024-03-01 | Buy |
| TCI Chemical | E0440 | Ethoxycarbonyl Isothiocyanate >95.0%(GC) | 16182-04-0 | 25g | $88 | 2024-03-01 | Buy |
| Alfa Aesar | L00911 | Ethoxycarbonyl isothiocyanate, 97% | 16182-04-0 | 5g | $63.65 | 2024-03-01 | Buy |
Ethoxycarbonyl Isothiocyanate Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Oil
Uses
Ethoxycarbonyl isothiocyanate has been used in the synthesis of:
- pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
- fused thiophene derivatives, having antibacterial and antifungal activities
- 4-thiouracil derivatives
- thiocarbamides from stannylarenes
- 1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
- N-acylthioureas from aminodeoxy sugars
Uses
Versatile reagent for organic synthesis.
Ethoxycarbonyl isothiocyanate is used as a building block in the synthesis of various heterocycles. It is also used for the synthesis of 1,2,4-oxadiazolidine-3,5-dione. It is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Application
Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives.
Ethoxycarbonyl isothiocyanate has been used in the synthesis of:
pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
fused thiophene derivatives, having antibacterial and antifungal activities
4-thiouracil derivatives
thiocarbamides from stannylarenes
1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
N-acylthioureas from aminodeoxy sugars
Synthesis Reference(s)
Using Schiff base as a phase transfer catalyst, ethoxycarbonyl isothiocyanate was synthesized by reacting ethyl chloroformate with sodium thiocyanate. www.semanticscholar.org
General Description
Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives.
Hazard
Lachrymator.
Ethoxycarbonyl Isothiocyanate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Junhua Import and Export Co., LTD | +86-18503288844 +86-18503288844 | junhua1@hb-junhua.com | China | 978 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19809 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29859 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
View Lastest Price from Ethoxycarbonyl Isothiocyanate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-24 | Ethoxycarbonyl Isothiocyanate
16182-04-0
|
US $0.00-0.00 / kg | 1kg | 99% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-04-23 | Ethoxycarbonyl Isothiocyanate
16182-04-0
|
US $10.00 / KG | 1KG | 99% | 5tons | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-03-21 | Ethoxycarbonyl Isothiocyanate
16182-04-0
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |
-
- Ethoxycarbonyl Isothiocyanate
16182-04-0
- US $0.00-0.00 / kg
- 99%
- Hebei Junhua Import and Export Co., LTD
-
- Ethoxycarbonyl Isothiocyanate
16182-04-0
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethoxycarbonyl Isothiocyanate
16182-04-0
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd