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Ethoxycarbonyl Isothiocyanate

CAS No.
16182-04-0
Chemical Name:
Ethoxycarbonyl Isothiocyanate
Synonyms
O-ethyl carbonisothiocyanatidate;ethyl N-carbothioylcarbamate;ETHYL ISOTHIOCYANATOFORMATE;Ethyl carbonisothiocyanatidate;NSC 158480;CARBETHOXYISOTHIOCYANATE;Ethoxycarbonyl Mustard Oil;ETHOXYCARBONYL ISOTHIOCYANATE;ETHYL ISOTHIOCYANATOFORMATE,98%;Ethyl isothiocyanatidocarbonate
CBNumber:
CB1265381
Molecular Formula:
C4H5NO2S
Molecular Weight:
131.15
MDL Number:
MFCD00004814
MOL File:
16182-04-0.mol
MSDS File:
SDS
Last updated:2025-03-10 17:18:44

Ethoxycarbonyl Isothiocyanate Properties

Boiling point 56 °C18 mm Hg(lit.)
Density 1.112 g/mL at 25 °C(lit.)
refractive index n20/D 1.500(lit.)
Flash point 123 °F
storage temp. 2-8°C
solubility Soluble in chloroform and ether.
form Oil
color Light Yellow
Specific Gravity 1.112
Sensitive Moisture Sensitive/Lachrymatory
BRN 606091
InChIKey BDTDECDAHYOJRO-UHFFFAOYSA-N
CAS DataBase Reference 16182-04-0(CAS DataBase Reference)
FDA UNII WQY39AV49E
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H226-H315-H317-H319-H331-H334-H335
Precautionary statements  P210-P280-P302+P352-P304+P340+P311-P305+P351+P338
Hazard Codes  T,Xi
Risk Statements  23-36/37/38-42
Safety Statements  23-26-36/37/39-45
RIDADR  UN 2929 6.1/PG 2
WGK Germany  3
9-13-19-21
HazardClass  3
PackingGroup  III
HS Code  29309090
NFPA 704
2
3 1

Ethoxycarbonyl Isothiocyanate price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 196126 Ethoxycarbonyl isothiocyanate 98% 16182-04-0 5g $89.6 2024-03-01 Buy
Sigma-Aldrich 196126 Ethoxycarbonyl isothiocyanate 98% 16182-04-0 25g $260 2024-03-01 Buy
TCI Chemical E0440 Ethoxycarbonyl Isothiocyanate >95.0%(GC) 16182-04-0 5g $26 2024-03-01 Buy
TCI Chemical E0440 Ethoxycarbonyl Isothiocyanate >95.0%(GC) 16182-04-0 25g $88 2024-03-01 Buy
Alfa Aesar L00911 Ethoxycarbonyl isothiocyanate, 97% 16182-04-0 5g $63.65 2024-03-01 Buy
Product number Packaging Price Buy
196126 5g $89.6 Buy
196126 25g $260 Buy
E0440 5g $26 Buy
E0440 25g $88 Buy
L00911 5g $63.65 Buy

Ethoxycarbonyl Isothiocyanate Chemical Properties,Uses,Production

Chemical Properties

Light Yellow Oil

Uses

Ethoxycarbonyl isothiocyanate has been used in the synthesis of:

  • pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
  • fused thiophene derivatives, having antibacterial and antifungal activities
  • 4-thiouracil derivatives
  • thiocarbamides from stannylarenes
  • 1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
  • N-acylthioureas from aminodeoxy sugars

Uses

Versatile reagent for organic synthesis.
Ethoxycarbonyl isothiocyanate is used as a building block in the synthesis of various heterocycles. It is also used for the synthesis of 1,2,4-oxadiazolidine-3,5-dione. It is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Application

Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives.
Ethoxycarbonyl isothiocyanate has been used in the synthesis of:
pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
fused thiophene derivatives, having antibacterial and antifungal activities
4-thiouracil derivatives
thiocarbamides from stannylarenes
1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
N-acylthioureas from aminodeoxy sugars

Synthesis Reference(s)

Using Schiff base as a phase transfer catalyst, ethoxycarbonyl isothiocyanate was synthesized by reacting ethyl chloroformate with sodium thiocyanate. www.semanticscholar.org

General Description

Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives.

Hazard

Lachrymator.

540-72-7
541-41-3
16182-04-0
Synthesis of Ethoxycarbonyl Isothiocyanate from Sodium thiocyanate and Ethyl chloroformate
Global( 265)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd
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View Lastest Price from Ethoxycarbonyl Isothiocyanate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethoxycarbonyl Isothiocyanate pictures 2025-03-28 Ethoxycarbonyl Isothiocyanate
16182-04-0
US $0.00 / kg 1kg 98% 1000 Hebei Junhua Import and Export Co., LTD
Ethoxycarbonyl Isothiocyanate pictures 2025-03-28 Ethoxycarbonyl Isothiocyanate
16182-04-0
US $10.00 / KG 1KG 99% 5tons Hebei Chuanghai Biotechnology Co., Ltd
Ethoxycarbonyl Isothiocyanate pictures 2025-03-21 Ethoxycarbonyl Isothiocyanate
16182-04-0
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
Ethyl isothiocyanatidocarbonate ETHYL ISOTHIOCYANATOFORMATE,98% (Ethoxyoxomethyl) isothiocyanate Ethoxy(oxo)methyl isothiocyanate Isothiocyanatoformic acid ethyl CARBETHOXYISOTHIOCYANATE CARBON(ISOTHIOCYANATIDIC)ACID, ETHYL ESTER ISOTHIOCYANATOFORMIC ACID ETHYL ESTER ETHOXYCARBONYL ISOTHIOCYANATE Isothiocyanoformic acid ethyl ester Ethoxycarbonyl isothiocyanate,95% Ethoxycarbonyl isothiocyanate,Ethyl isothiocyanatoformate Carbonic Acid Ethyl Ester Isothiocyanate Ethoxycarbonyl Mustard Oil NSC 158480 Ethyl Isothiocyanatoformate Isothiocyanatoformic Acid Ethyl Ester Ethyl isothiocyanatoformate, Ethoxycarbonyl isothiocyanate Ethoxycarbonyl isothiocyanate 98% ethyl N-(sulfanylidenemethylidene)carbamate Ethoxycarbonylisothiocyanate,97% Ethyl carbonisothiocyanatidate 98% EthoxycarbonylIsothiocyanate> ETHYL ISOTHIOCYANATOFORMATE Ethyl carbonisothiocyanatidate O-ethyl carbonisothiocyanatidate ethyl N-carbothioylcarbamate 16182-04-0 C4H5N02S C4H5NO2S SCNCOOCH2CH3 ISOTHIOCYANATE Building Blocks Organic Building Blocks Sulfur Compounds Thiocyanates/Isothiocyanates Miscellaneous Reagents