|
| Ethoxycarbonyl Isothiocyanate Basic information |
Product Name: | Ethoxycarbonyl Isothiocyanate | Synonyms: | Ethyl isothiocyanatidocarbonate;ETHYL ISOTHIOCYANATOFORMATE,98%;(Ethoxyoxomethyl) isothiocyanate;Ethoxy(oxo)methyl isothiocyanate;Isothiocyanatoformic acid ethyl;CARBETHOXYISOTHIOCYANATE;CARBON(ISOTHIOCYANATIDIC)ACID, ETHYL ESTER;ISOTHIOCYANATOFORMIC ACID ETHYL ESTER | CAS: | 16182-04-0 | MF: | C4H5NO2S | MW: | 131.15 | EINECS: | 240-318-9 | Product Categories: | Miscellaneous Reagents | Mol File: | 16182-04-0.mol | ![Ethoxycarbonyl Isothiocyanate Structure](CAS/GIF/16182-04-0.gif) |
| Ethoxycarbonyl Isothiocyanate Chemical Properties |
Boiling point | 56 °C18 mm Hg(lit.) | density | 1.112 g/mL at 25 °C(lit.) | refractive index | n20/D 1.500(lit.) | Fp | 123 °F | storage temp. | 2-8°C | solubility | Soluble in chloroform and ether. | form | Oil | color | Light Yellow | Specific Gravity | 1.112 | Sensitive | Moisture Sensitive/Lachrymatory | BRN | 606091 | InChIKey | BDTDECDAHYOJRO-UHFFFAOYSA-N | CAS DataBase Reference | 16182-04-0(CAS DataBase Reference) |
| Ethoxycarbonyl Isothiocyanate Usage And Synthesis |
Chemical Properties | Light Yellow Oil | Uses | Ethoxycarbonyl isothiocyanate has been used in the synthesis of:
- pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2
- fused thiophene derivatives, having antibacterial and antifungal activities
- 4-thiouracil derivatives
- thiocarbamides from stannylarenes
- 1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines
- N-acylthioureas from aminodeoxy sugars
| Uses | Versatile reagent for organic synthesis. Ethoxycarbonyl isothiocyanate is used as a building block in the synthesis of various heterocycles. It is also used for the synthesis of 1,2,4-oxadiazolidine-3,5-dione. It is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. | Application | Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives. Ethoxycarbonyl isothiocyanate has been used in the synthesis of: pyrazolo[1,5-a][1,3,5]triazine derivatives, potential inhibitors of protein kinase CK2 fused thiophene derivatives, having antibacterial and antifungal activities 4-thiouracil derivatives thiocarbamides from stannylarenes 1,3,5-triazin-2-one-4-thiones from 2-amino-2-oxazolines N-acylthioureas from aminodeoxy sugars | Synthesis Reference(s) | Using Schiff base as a phase transfer catalyst, ethoxycarbonyl isothiocyanate was synthesized by reacting ethyl chloroformate with sodium thiocyanate. www.semanticscholar.org | General Description | Ethoxycarbonyl isothiocyanate reacts with 2-amino-tetrahydrobenzo[b]thiophene derivatives to yield tetrahydrobenzo[b]thiophen-2-thiourea derivatives. | Hazard | Lachrymator. |
| Ethoxycarbonyl Isothiocyanate Preparation Products And Raw materials |
|