ChemicalBook >> CAS DataBase List >>c-GpAp
c-GpAp
- CAS No.
- 849214-04-6
- Chemical Name:
- c-GpAp
- Synonyms
- cGAMP;c-GpAp;di-GAMP;di-cGAMP;3'3'-cGAMP;3'3'-cGAMP;Cyclic GMP-AMP;cGAMP free acid;cGAMP ammonium salt;cGAMP 3',3'-cGAMP
- CBNumber:
- CB12695700
- Molecular Formula:
- C20H24N10O13P2
- Molecular Weight:
- 674.41
- MDL Number:
- MFCD28411367
- MOL File:
- 849214-04-6.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
c-GpAp price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1232 | cGAMP sodium salt ≥98% (HPLC) | 849214-04-6 | .5UMO | $211 | 2023-06-20 | Buy |
TRC | G110500 | c-GpAp | 849214-04-6 | 10mg | $13390 | 2021-12-16 | Buy |
ChemScene | CS-3892 | cGAMP 99.22% | 849214-04-6 | 10mg | $2150 | 2021-12-16 | Buy |
ChemScene | CS-3892 | cGAMP 99.22% | 849214-04-6 | 25mg | $3750 | 2021-12-16 | Buy |
Biosynth Carbosynth | NC137624 | 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate | 849214-04-6 | 500ug | $300 | 2021-12-16 | Buy |
c-GpAp Chemical Properties,Uses,Production
Uses
cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.
Uses
c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.
Definition
ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-).
Biochem/physiol Actions
cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.
storage
+4°C
c-GpAp Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 88)Suppliers
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c-GpAp
di-GAMP
di-cGAMP
cGAMP (Cyclic GMP-AMP
3''-Guanylic acid, adenylyl-(3''?5'')-, cyclic nucleotide
3',3'-Cyclic guanosine monophosphate-adenosine monophosphate
cGAMP
3'3'-cGAMP
RFCBNSCSPXMEBK-XRIIRFCZSA-N
c-(ApGp) / 3'3'-cGAMP
Cyclic GMP-AMP
cGAMP ammonium salt
cGAMP free acid
cGAMP 3',3'-cGAMP
2-Amino-9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-3,9-dihydro-6H-purin-6-one
2-Amino-9-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-3,9-dihydro-6H-purin-6-one
3'3'-cGAMP
849214-04-6
C20H22N10O13P22Na
Nucleotides, Bases & Related Reagents, Derivatives