(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
- CAS No.
- 608141-43-1
- Chemical Name:
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
- Synonyms
- Apremilast Impurity 62;RSSYY(Lurasidone Hydrochloride)-15;(2S)-2-acetamido-4-methylpentanoate;Apremilast Impurity 2 N-Acetyl-L-Leucine Salt;Apremilast Impurity 4 N-Acetyl-L-Leucine Salt;Apremilast Impurity 35 N-acetyl-L-leucine Salt;Apremilast Impurity 21 N-Acetyl-L-Leucine Salt;Apremilast Impurity 55(N-Acetyl-L-leucine Salt);(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin...;[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]azanium
- CBNumber:
- CB12707852
- Molecular Formula:
- C20H34N2O7S
- Molecular Weight:
- 446.56
- MDL Number:
- MFCD28167941
- MOL File:
- 608141-43-1.mol
- MSDS File:
- SDS
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
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CAS DataBase Reference | 608141-43-1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt price More Price(12)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | E898128 | (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-Acetyl-L-leucineSalt | 608141-43-1 | 500mg | $60 | 2021-12-16 | Buy |
ChemScene | CS-M2810 | (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-acetyl-L-leucinesalt 99.99% | 608141-43-1 | 10g | $70 | 2021-12-16 | Buy |
ChemScene | CS-M2810 | (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamineN-acetyl-L-leucinesalt 99.99% | 608141-43-1 | 100g | $375 | 2021-12-16 | Buy |
Activate Scientific | AS93594 | (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine N-Acetyl-L-leucine Salt 95+% ee | 608141-43-1 | 25g | $443 | 2021-12-16 | Buy |
Chemenu | CM186592 | (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amineacetyl-L-leucinate 95+% | 608141-43-1 | 10g | $130 | 2021-12-16 | Buy |
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Chemical Properties,Uses,Production
Synthesis
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt is prepared by the reaction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine and N-Acetyl-L-leucine. The specific synthesis steps are as follows:
A 3 L 3-necked round bottom flask was equipped with a mechanical stirrer, thermometer, and condenser and charged with 2-(3 -ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine (137.0 g, 500 mmol), N-acetyl-L-leucine (52 g, 300 mmol), and methanol (1.0 L). The stirred slurry was heated to reflux for 1 hour. The stirred mixture was allowed to cool to ambient temperature and stirring was continued for another 3 hours at ambient temperature. The slurry was filtered andwashed with methanol (250 mL). The solid was air-dried and then dried in vacuo at ambient temperature to a constant weight, giving 109.5 g (98percent yield) of the crude product (85.8percent ee). The crude solid (55.0 g) and methanol (440 mL) were brought to reflux for 1 hour, cooled to room temperature and stirred for an additional 3 hours at ambient temperature. The slurry was filtered and the filter cake was washed with methanol (200 mL). The solid was air-dried and then dried invacuo at 30°C. to a constant weight, yielding 49.6 g (90percent recovery) of(S)-2-(3-ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine-N-acety l-L-leucine salt (98.4percent ee). ChiralHPLC (1/99 EtOH/20 mM KH2PO4 pH 7.0, Ultron Chiral ES-OVS from Agilent Technologies,150 mm4.6 mm, 0.5 mL/min., 240 nm): 18.4 mm (S-isomer, 99.2percent), 25.5 mm (R-isomer,0.8percent).
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16208 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21671 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29897 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
Jinan Honest Pharm Co., Ltd | +8615318812076 | zpy8217@163.com | China | 286 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 11973 | 58 |
View Lastest Price from (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2023-11-01 | (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
608141-43-1
|
US $0.00-0.00 / kg | 1kg | 99% | ≥1kg | Hangzhou ICH Biofarm Co., Ltd | |
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2022-09-14 | (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine salt
608141-43-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
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2019-07-06 | (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
608141-43-1
|
US $100.00 / KG | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
608141-43-1
- US $0.00-0.00 / kg
- 99%
- Hangzhou ICH Biofarm Co., Ltd
-
- (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine N-acetyl-L-leucine salt
608141-43-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
608141-43-1
- US $100.00 / KG
- 98%
- Career Henan Chemical Co
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