(S)-1-(3-에톡시-4-메톡시페닐)-2-(메틸술포닐)에틸라민N-아세틸-L-류신염
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(S)-1-(3-에톡시-4-메톡시페닐)-2-(메틸술포닐)에틸라민N-아세틸-L-류신염 속성
- 저장 조건
- Inert atmosphere,Store in freezer, under -20°C
- CAS 데이터베이스
- 608141-43-1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Warning | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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(S)-1-(3-에톡시-4-메톡시페닐)-2-(메틸술포닐)에틸라민N-아세틸-L-류신염 C화학적 특성, 용도, 생산
Synthesis
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt is prepared by the reaction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine and N-Acetyl-L-leucine. The specific synthesis steps are as follows:A 3 L 3-necked round bottom flask was equipped with a mechanical stirrer, thermometer, and condenser and charged with 2-(3 -ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine (137.0 g, 500 mmol), N-acetyl-L-leucine (52 g, 300 mmol), and methanol (1.0 L). The stirred slurry was heated to reflux for 1 hour. The stirred mixture was allowed to cool to ambient temperature and stirring was continued for another 3 hours at ambient temperature. The slurry was filtered andwashed with methanol (250 mL). The solid was air-dried and then dried in vacuo at ambient temperature to a constant weight, giving 109.5 g (98percent yield) of the crude product (85.8percent ee). The crude solid (55.0 g) and methanol (440 mL) were brought to reflux for 1 hour, cooled to room temperature and stirred for an additional 3 hours at ambient temperature. The slurry was filtered and the filter cake was washed with methanol (200 mL). The solid was air-dried and then dried invacuo at 30°C. to a constant weight, yielding 49.6 g (90percent recovery) of(S)-2-(3-ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine-N-acety l-L-leucine salt (98.4percent ee). ChiralHPLC (1/99 EtOH/20 mM KH2PO4 pH 7.0, Ultron Chiral ES-OVS from Agilent Technologies,150 mm4.6 mm, 0.5 mL/min., 240 nm): 18.4 mm (S-isomer, 99.2percent), 25.5 mm (R-isomer,0.8percent).
(S)-1-(3-에톡시-4-메톡시페닐)-2-(메틸술포닐)에틸라민N-아세틸-L-류신염 준비 용품 및 원자재
원자재
준비 용품
(S)-1-(3-에톡시-4-메톡시페닐)-2-(메틸술포닐)에틸라민N-아세틸-L-류신염 공급 업체
글로벌( 187)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16208 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21671 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29897 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 |
export01@shyrchem.com | CHINA | 1320 | 58 |
Jinan Honest Pharm Co., Ltd | +8615318812076 |
zpy8217@163.com | China | 286 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 |
marketing1@neostarunited.com | China | 11973 | 58 |
(S)-1-(3-에톡시-4-메톡시페닐)-2-(메틸술포닐)에틸라민N-아세틸-L-류신염 관련 검색:
Apremilast Impurity 9
Apremilast Impurity 2
APST-ZA
(R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
(S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
3-acetamidophthalic acid
Apremilast Impurity E
Apremilast Impurity 1
Apremilast Impurity 13
Apremilast Impurity 8
Apremilast Impurity 1/2
Apremilast
ApreMilast-d5
Apremilast impurity 15
Apremilast Impurity F
Apremilast Impurity C
[[p-(2-methoxyethyl)phenoxy]methyl]oxirane
Apremilast Impurity 10