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ChemicalBook >> CAS DataBase List >>Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]-

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]-

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Structure
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- structure
CAS No.
1431411-66-3
Chemical Name:
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]-
Synonyms
SIRT-IN-2;Inhibitor,SIRT IN 2,inhibit,Sirtuin,SIRTIN2;4-[4-[2-(methanesulfonamido)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide;4-[4-[2-[(methylsulfonyl)amino]ethyl]-1-piperidinyl]-Thieno[3,2-d]pyrimidine-6-carboxamide;Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]-
CBNumber:
CB12716388
Molecular Formula:
C15H21N5O3S2
Molecular Weight:
383.49
MDL Number:
MFCD28386340
MOL File:
1431411-66-3.mol
Last updated:2024-07-02 08:55:00
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Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color Yellow to brown

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0009172 SIRT-IN-2 1431411-66-3 5mg $380 2021-12-16 Buy
ChemScene CS-0009172 SIRT-IN-2 1431411-66-3 10mg $650 2021-12-16 Buy
ChemScene CS-0009172 SIRT-IN-2 1431411-66-3 50mg $1800 2021-12-16 Buy
ChemScene CS-0009172 SIRT-IN-2 1431411-66-3 100mg $2800 2021-12-16 Buy
Product number Packaging Price Buy
CS-0009172 5mg $380 Buy
CS-0009172 10mg $650 Buy
CS-0009172 50mg $1800 Buy
CS-0009172 100mg $2800 Buy

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Chemical Properties,Uses,Production

Description

SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.

SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].

References

[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- synthesis

16269-66-2
1431411-66-3
Synthesis of Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- from 4-Chlorothieno[3,2-d]pyrimidine

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Suppliers

Global( 11)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 377 55
SPIRO PHARMA eric_feng1954@126.com China 9254 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8013 62
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
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cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10011 58
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RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9282 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Beckham Medical Technology Co., Ltd 55
SPIRO PHARMA 55
ShangHai Biochempartner Co.,Ltd 62
Fan De(Beijing) Biotechnology Co., Ltd. 58
Suzhou Rovathin Foreign Trade Co.,Ltd 58
cjbscvictory 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- 4-[4-[2-[(methylsulfonyl)amino]ethyl]-1-piperidinyl]-Thieno[3,2-d]pyrimidine-6-carboxamide 4-[4-[2-(methanesulfonamido)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide SIRT-IN-2 Inhibitor,SIRT IN 2,inhibit,Sirtuin,SIRTIN2 1431411-66-3