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2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- structure

CAS No.: 1374356-45-2

Chemical Name:: 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Synonyms: (s)-g-fitinib;(S)-CRIZOTINIB;ent-crizotinib;Crizotinib, (S)-;Crizotinib S-Isomer;Crizotinib impurity A;Crizotinib Impurity 24;CRIZOTINIB, S-ENANTIOMER;CRIZOTINIB CHIRAL IMPURITY;3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

CBNumber:: CB12729650

Molecular Formula:: C21H22Cl2FN5O

Molecular Weight:: 450.34

MDL Number:: MFCD22126092

MOL File:: 1374356-45-2.mol

MSDS File:: SDS

Last updated:2024-11-19 15:53:33

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2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Properties

Boiling point	599.2±50.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 0.5 mg/ml
form	A solid
pka	9.81±0.10(Predicted)
color	Light yellow to yellow
CAS DataBase Reference	1374356-45-2

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	6025	(S)-Crizotinib ≥98%(HPLC)	1374356-45-2	10	$137	2021-12-16	Buy
Tocris	6025	(S)-Crizotinib ≥98%(HPLC)	1374356-45-2	50	$578	2021-12-16	Buy
TRC	C785005	(S)-Crizotinib	1374356-45-2	5mg	$275	2021-12-16	Buy
TRC	C785005	(S)-Crizotinib	1374356-45-2	2.5mg	$180	2021-12-16	Buy
TRC	C785005	(S)-Crizotinib	1374356-45-2	1mg	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
6025	10	$137	Buy
6025	50	$578	Buy
C785005	5mg	$275	Buy
C785005	2.5mg	$180	Buy
C785005	1mg	$80	Buy

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Chemical Properties,Uses,Production

Characteristics

MTH1 (NUDT1)-selective inhibitor.

Uses

(S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent.

Definition

ChEBI: Ent-crizotinib is a 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. It is an enantiomer of a crizotinib.

Biological Activity

(S)-crizotinib, (S)enantiomer-crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

target

Target	Value
MTH1 (Cell-free assay)	72 nM

storage

Store at RT

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Suppliers

Global( 85)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29810	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15352	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9311	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Guangzhou CATO Research Chemicals Inc.	+86-020-81960175-617 +8615602392859	Intermediate@cato-chem.com	China	8322	58

Supplier	Advantage
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Guangzhou CATO Research Chemicals Inc.	58

View Lastest Price from 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	(S)-crizotinib 1374356-45-2	US $39.00-97.00 / mg		99.89%	10g	TargetMol Chemicals Inc.
	2020-02-02	2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- 1374356-45-2	US $1.00 / g	1g	99%	200g	Career Henan Chemical Co

(S)-crizotinib
1374356-45-2
US $39.00-97.00 / mg
99.89%
TargetMol Chemicals Inc.

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
1374356-45-2
US $1.00 / g
99%
Career Henan Chemical Co

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Spectrum

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-(1374356-45-2)¹HNMR

1374356-45-2(2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-)Related Search:

Lead Selenium Diethyl sulfate LEUHISTIN Angeli’s Salt

Lignosulfonic acid Everolimus KU-55933 (ATM Kinase Inhibitor) Sunitinib Malate Crizotinib

TH588 AZD-9291

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(S)-CRIZOTINIB 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Crizotinib impurity A CRIZOTINIB CHIRAL IMPURITY (s)-g-fitinib Crizotinib S-Isomer Crizotinib Impurity 24 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine Crizotinib, (S)- ent-crizotinib mutT,inhibit,nucleotide,Apoptosis,(S) crizotinib,homologue,Inhibitor,activity,anticancer,pool,(S)-Crizotinib,(S)crizotinib,DNA/RNA Synthesis CRIZOTINIB, S-ENANTIOMER 1374356-45-2 Inhibitors