Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride Properties

Melting point	243 °C (dec.)(lit.)
Flash point	9℃
storage temp.	-20°C
solubility	ethanol: soluble5mg/mL
pka	pK1 3.9, pK2 8.1(at 25℃)
form	powder
color	white to off-white
λmax	312nm(MeOH)(lit.)
Merck	14,9680
BRN	3820024
Stability	Hygroscopic
CAS DataBase Reference	440-17-5(CAS DataBase Reference)
FDA UNII	6P1Y2SNF5V
NCI Drug Dictionary	Stelazine
EPA Substance Registry System	10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08,GHS09

Signal word

Danger

Hazard statements

H302-H319-H336-H341-H372-H410

Precautionary statements

P201-P273-P301+P312+P330-P305+P351+P338-P308+P313

Hazard Codes

Xn

Risk Statements

22

Safety Statements

36

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

3

RTECS

SP1750000

F

3-10

HS Code

29343000

NFPA 704

	0
2		0

Trifluoperazine dihydrochloride price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T-117	Trifluoperazine dihydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?	440-17-5	1mL	$172	2024-03-01	Buy
Sigma-Aldrich	1685000	Trifluoperazine hydrochloride United States Pharmacopeia (USP) Reference Standard	440-17-5	200mg	$261.6	2024-03-01	Buy
TCI Chemical	T2849	Trifluoperazine Dihydrochloride >98.0%(HPLC)(T)	440-17-5	5g	$100	2024-03-01	Buy
TCI Chemical	T2849	Trifluoperazine Dihydrochloride >98.0%(HPLC)(T)	440-17-5	25g	$347	2024-03-01	Buy
Cayman Chemical	15068	Trifluoperazine (hydrochloride) ≥98%	440-17-5	1g	$32	2024-03-01	Buy

Product number	Packaging	Price	Buy
T-117	1mL	$172	Buy
1685000	200mg	$261.6	Buy
T2849	5g	$100	Buy
T2849	25g	$347	Buy
15068	1g	$32	Buy

Trifluoperazine dihydrochloride Chemical Properties,Uses,Production

Description

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α₁ over the α₂ subtypes (K_is = 24, 653, 163, and 391 nM for α_1A, α_2A, α_2B, and α_2C, respectively). TFP binds with much higher affinity to the dopamine D₂-like receptor (K_d = 0.96 nM) compared to the dopamine D₄-like and the serotonin 5-HT_2A receptors (K_ds = 44 and 135 nM, respectively). Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ). TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.

Chemical Properties

Cream Fine Powder

Originator

Stelazine,SKF,US,1958

Uses

Antipsychotic

Uses

Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux.

Manufacturing Process

A mixture of 17.2 grams of 2-trifluoromethylphenothiazine, 3.1 grams of sodamide and 14 grams of 1-(3'-chloropropyl)-4-methylpiperazine in 200 ml of xylene is heated at reflux for 2 hours. The salts are extracted into 150 ml of water. The xylene layer is then extracted with several portions of dilute hydrochloric acid. The acid extracts are combined and neutralized with ammonium hydroxide solution. The product, 10-[3'-(4''-methyl-1''- piperazinyl)-propyl]-2-trifluoromethylphenothiazine, is taken into benzene and purified by vacuum distillation, BP 202° to 210°C at 0.6 mm.

Therapeutic Function

Tranquilizer

General Description

Trifluoperazinehydrochloride, 10-[3-(4-Methyl-1-piperazinyl)propyl-[2-(trifluoromethyl)phenothiazine dihydrochloride (Stelazine).The absorption of trifluoperazine is erratic and variable andit is widely distributed into tissues. The excretion of trifluoperazineoccurs 50% via kidneys and the other 50% isthrough enterohepatic circulation. The metabolism and druginteractions of trifluoperazine are the same as with the otherphenothiazines. Trifluoperazine does not show any specificdrug interactions. Trifluoperazine is indicated for the managementof schizophrenia and short-term treatment ofnonpsychotic anxiety.

Biochem/physiol Actions

Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F-, NOx, SOx, and HCl. See also FLUORIDES.

Purification Methods

Recrystallise the salt from absolute EtOH, filter the crystals, dry them in vacuo and store them in tightly stoppered bottles because it is hygroscopic. It is soluble in H2O but insoluble in *C6H6, Et2O and alkaline aqueous solution. It has UV at 258 and 307.5nm (log 4.50 and 3.50) in EtOH (neutral species). [Craig max et al. J Org Chem 22 709 1957.] It is a calmodulin inhibitor [Levene & Weiss J Parmacol Exptl Ther 208 454 1978] and is a psychotropic agent [Fowler Arzneim.-Forsch 27 866 1977]. [Beilstein 27 III/IV 1353.]

Trifluoperazine dihydrochloride Preparation Products And Raw materials

Raw materials

1-Methyl-4-(3-chloropropyl)piperazine 2-(Trifluoromethyl)phenothiazine Sodium amide

Preparation Products

trifluoperazine sulfoxide

Trifluoperazine dihydrochloride Suppliers

Global( 236)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD	+8615377521700	wangwendy93@gmail.com	China	868	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34553	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15354	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9314	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9414	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Baoji Guokang Healthchem co.,ltd	58

View Lastest Price from Trifluoperazine dihydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Trifluoperazine dihydrochloride 440-17-5	US $50.00 / mg		99.96%	10g	TargetMol Chemicals Inc.
2024-11-19	Trifluoperazine dihydrochloride 440-17-5	US $50.00 / mg		99.96%	10g	TargetMol Chemicals Inc.
2024-03-16	Trifluoperazine dihydrochloride 440-17-5	US $0.00 / KG	100g	98%+	100kg	WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Trifluoperazine dihydrochloride
440-17-5
US $50.00 / mg
99.96%
TargetMol Chemicals Inc.

Trifluoperazine dihydrochloride
440-17-5
US $50.00 / mg
99.96%
TargetMol Chemicals Inc.

Trifluoperazine dihydrochloride
440-17-5
US $0.00 / KG
98%+
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Trifluoperazine dihydrochloride Spectrum

Trifluoperazine dihydrochloride(440-17-5)MS Trifluoperazine dihydrochloride(440-17-5)¹HNMR Trifluoperazine dihydrochloride(440-17-5)IR

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