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ChemicalBook >> CAS DataBase List >>Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Structure
Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate structure
CAS No.
922507-80-0
Chemical Name:
Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
Synonyms
16F16,16F-16;PDI inhibitor 16F16;PDI inhibitor 16F16 >=98% (HPLC);Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate;2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester;1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-, methyl ester
CBNumber:
CB12751042
Molecular Formula:
C16H17ClN2O3
Molecular Weight:
320.77
MDL Number:
MFCD20134198
MOL File:
922507-80-0.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:14
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Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Properties

storage temp. 2-8°C
solubility DMSO: soluble12mg/mL, clear
form powder
color white to tan

SAFETY

Risk and Safety Statements

WGK Germany  3

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0021 PDI inhibitor 16F16 ≥98% (HPLC) 922507-80-0 5mg $147 2024-03-01 Buy
Sigma-Aldrich SML0021 PDI inhibitor 16F16 ≥98% (HPLC) 922507-80-0 25mg $581 2024-03-01 Buy
AK Scientific 9008CM Methyl2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate 922507-80-0 25mg $785 2021-12-16 Buy
Product number Packaging Price Buy
SML0021 5mg $147 Buy
SML0021 25mg $581 Buy
9008CM 25mg $785 Buy

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Chemical Properties,Uses,Production

Uses

PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.

Biochem/physiol Actions

16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
JiangSu Star Science Co.,Ltd 400-605-7200 17312445705 sales022@b2star.com China 3764 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29803 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7984 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
Sigma-Aldrich 80
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
JiangSu Star Science Co.,Ltd 58
TargetMol Chemicals Inc. 58
Shanghai Maclean Biochemical Technology Co., LTD 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate PDI inhibitor 16F16 2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester 1H-Pyrido[3,4-b]indole-1-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-, methyl ester PDI inhibitor 16F16 >=98% (HPLC) 16F16,16F-16 922507-80-0