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ANTIPAIN, DIHYDROCHLORIDE

CAS No.
37682-72-7
Chemical Name:
ANTIPAIN, DIHYDROCHLORIDE
Synonyms
ANTIPAIN;BDBM32804;BDBM 32804;BDBM-32804;Antipain HCl;Antipain 2HCI;ANTIPAIN (2HCL);BDBM 32804, Antipain;ANTIPAIN HYDROCHLORIDE;Phe-Arg-Val-Arg-CHO.2HCl
CBNumber:
CB1279463
Molecular Formula:
C27H46Cl2N10O6
Molecular Weight:
677.62
MDL Number:
MFCD00135957
MOL File:
37682-72-7.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

ANTIPAIN, DIHYDROCHLORIDE Properties

Melting point 209-217 °C
Boiling point 652.92°C (rough estimate)
Density 1.2423 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. -20°C
solubility H2O: 50 mg/mL
form White powder
color White
Water Solubility 0.01M in water
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
FDA UNII GWZ8LOU6OG

SAFETY

Risk and Safety Statements

Precautionary statements  P261-P271-P280
Safety Statements  22-24/25
WGK Germany  3
RTECS  YV9350800
1-10
HS Code  2934999090

ANTIPAIN, DIHYDROCHLORIDE price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 178220 Antipain, Hydrochloride 37682-72-7 5mg $85.2 2024-03-01 Buy
Sigma-Aldrich 178220 Antipain, Hydrochloride 37682-72-7 10mg $144 2024-03-01 Buy
Sigma-Aldrich 11004646001 Antipain dihydrochloride 37682-72-7 10mg $244 2024-03-01 Buy
Alfa Aesar J63680 Antipain dihydrochloride 37682-72-7 5mg $73.65 2024-03-01 Buy
Cayman Chemical 26705 Antipain (hydrochloride) 37682-72-7 5mg $43 2024-03-01 Buy
Product number Packaging Price Buy
178220 5mg $85.2 Buy
178220 10mg $144 Buy
11004646001 10mg $244 Buy
J63680 5mg $73.65 Buy
26705 5mg $43 Buy

ANTIPAIN, DIHYDROCHLORIDE Chemical Properties,Uses,Production

Description

Antipain is a protease inhibitor originally isolated from actinomycetes. It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC50s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N''-nitro-N-nitroso-guanidine (MNNG). In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice.

Uses

Antipain inhibits trypsin, papain, and catherpsins A and B (a reversible inhibitor of cysteine and serine proteases). It is used to evaluate the role of proteases in cell transformations. It is used to help identify new proteases.

Uses

Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM

General Description

Antipain is a protease inhibitor isolated from actinomycetes. It inhibits thrombokinase and blood coagulation.

Biochem/physiol Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

References

1) Umezawa?et al.?(1976),?Structures and activities of protease inhibitors of microbial origin; Method Enzymol.,?45?678 2) Gotoh?et al.?(2001),?Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors; J. Biosci. Bioeng.,?92?248 3) Hockensmith?et al. (2016), Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia; Microb. Pathog.,?100?37 4) Mat Amin?et al. (2004),?Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.; Trop. Biomed.,?21?57 5) Moriyyasu & Inoue (2008),?Use of protease inhibitor for detecting autophagy in plants; Methods Enzymol.,?451?557

ANTIPAIN, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 105)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Wuhan Fortuna Chemical Co.,Ltd
+8618007136271 hk@fortunachem.com China 5998 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580 cooperation@kean-chem.com China 40066 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64

View Lastest Price from ANTIPAIN, DIHYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Antipain dihydrochloride pictures 2024-11-19 Antipain dihydrochloride
37682-72-7
US $69.00 / mg 95% 10g TargetMol Chemicals Inc.
N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HYDROCHLORIDE l-valinamide,n(sup2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-l-arginyl-n-( ANTIPAIN HYDROCHLORIDE FROMMICROBIAL SOU RCE L-Valinamide, N2-(1-carboxy-2-phenylethyl)aminocarbonyl-L-arginyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, dihydrochloride antipain dihydrochloride from microbial source n-(nα-carbonyl-arg-val-arg-al)-phe N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride TRIS-GLYCINE BUFFER 10X PWD PROTEOMICS N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2) L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, dihydrochloride Phe-Arg-Val-Arg-CHO.2HCl ANTIPAIN ;PHE-ARG-VAL-ARG-CHO.2HCL (9S,12S)-1-aMino-16-benzyl-6-forMyl-12-(3-guanidinopropyl)-1-iMino-9-isopropyl-8,11,14-trioxo-2,7,10,13,15-pentaazaheptadecan-17-oic acid dihydrochloride L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2) EZNA KIT ISOLATION FFPE RNA ANTIPAIN ANTIPAIN (2HCL) ANTIPAIN HYDROCHLORIDE [(S)-I-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-L-ARG-L-VAL-ARGINAL [(S)-1-CARBOXY-2-PHENETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE (S)-[1-CARBOXY-2-PHENYL-ETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARG-AL HYDROCHLORIDE [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARGINAL 2HCL [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-L-ARGININAL [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYL-ARGININAL [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYLARGININAL HYDROCHLORIDE N-(-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL)PHE N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HCL ANTIPAIN, DIHYDROCHLORIDE Antipain 2HCI Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem Antipain dihydrochloride from microbial source protease inhibitor Antipain HCl BDBM 32804 BDBM32804 BDBM-32804 BDBM 32804, Antipain Antipain 2HCl|||BDBM-32804|||BDBM 32804, Antipain|||BDBM32804 37682-72-7 C27H44N10O62HCl C27H44N10O62ClH C27H46Cl2N10O6 BioChemical Biochemicals and Reagents Antibiotics Analytical Enzymes Antibiotics A to Z Antibiotics A-F Enzymes, Inhibitors, and Substrates Trypsin Inhibitors peptides inhibitor AN-AZ Antineoplastic and Immunosuppressive Antibiotics Broad Spectrum Inhibitors of Proteolytic Enzyme Classes Cathepsin D Cysteine Protease Inhibitor