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ROR gamma-t-IN-1

ROR gamma-t-IN-1 structure

CAS No.: 1426802-50-7

Chemical Name:: ROR gamma-t-IN-1

Synonyms: GSK805;ROR gamma-t-IN-1;GSK805 (GSK-805);GSK805,N-(2,6-Dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-;4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one;N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide;N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide;Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-;N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide

CBNumber:: CB13048666

Molecular Formula:: C23H18Cl2F3NO4S

Molecular Weight:: 532.36

MDL Number:: MFCD28902182

MOL File:: 1426802-50-7.mol

Last updated:2024-11-19 15:53:33

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ROR gamma-t-IN-1 Properties

Boiling point	617.1±55.0 °C(Predicted)
Density	1.434±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM) DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM)
form	A crystalline solid
pka	12.33±0.70(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

ROR gamma-t-IN-1 price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	9002444	GSK805 ≥98%	1426802-50-7	1mg	$44	2024-03-01	Buy
Cayman Chemical	9002444	GSK805 ≥98%	1426802-50-7	5mg	$151	2024-03-01	Buy
Cayman Chemical	9002444	GSK805 ≥98%	1426802-50-7	10mg	$235	2024-03-01	Buy
ChemScene	CS-5079	GSK805 97.14%	1426802-50-7	10mg	$280	2021-12-16	Buy
AK Scientific	2948DU	RORgamma-t-IN-1	1426802-50-7	10mg	$360	2021-12-16	Buy

Product number	Packaging	Price	Buy
9002444	1mg	$44	Buy
9002444	5mg	$151	Buy
9002444	10mg	$235	Buy
CS-5079	10mg	$280	Buy
2948DU	10mg	$360	Buy

ROR gamma-t-IN-1 Chemical Properties,Uses,Production

Description

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4⁺ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.

ROR gamma-t-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

ROR gamma-t-IN-1 Suppliers

Global( 53)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1460	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Chengdu DingDang Pharmaceutical Co., Ltd.	028-86040038 13980902949;	market@dingdangchem.com	China	1843	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
Labnetwork lnc.	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Chemtour Biotech Co., Ltd	58
Amadis Chemical Company Limited	58
Chengdu DingDang Pharmaceutical Co., Ltd.	55

View Lastest Price from ROR gamma-t-IN-1 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	GSK805 1426802-50-7	US $51.00-123.00 / mg		≥95%	10g	TargetMol Chemicals Inc.

GSK805
1426802-50-7
US $51.00-123.00 / mg
≥95%
TargetMol Chemicals Inc.

1426802-50-7(ROR gamma-t-IN-1)Related Search:

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ROR gamma-t-IN-1 GSK805 GSK805 (GSK-805) N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)- N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide GSK805,N-(2,6-Dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)- N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide GSK 805,immunity,RAR-related orphan receptor,Inhibitor,GSK805,inhibit,ROR,oral,CNS penetrant,GSK-805,Th17 cell N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 1426802-50-7 C23H18Cl2F3NO4S