Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>ROR gamma-t-IN-1

ROR gamma-t-IN-1

ROR gamma-t-IN-1 Structure
ROR gamma-t-IN-1 structure
CAS No.
1426802-50-7
Chemical Name:
ROR gamma-t-IN-1
Synonyms
GSK805;ROR gamma-t-IN-1;GSK805 (GSK-805);GSK805,N-(2,6-Dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-;4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one;N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide;N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide;Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)-;N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide
CBNumber:
CB13048666
Molecular Formula:
C23H18Cl2F3NO4S
Molecular Weight:
532.36
MDL Number:
MFCD28902182
MOL File:
1426802-50-7.mol
Last updated:2023-06-08 09:03:09
Request For Quotation

ROR gamma-t-IN-1 Properties

Boiling point 617.1±55.0 °C(Predicted)
Density 1.434±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM)
DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM)
form A crystalline solid
pka 12.33±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

ROR gamma-t-IN-1 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 9002444 GSK805 ≥98% 1426802-50-7 1mg $44 2024-03-01 Buy
Cayman Chemical 9002444 GSK805 ≥98% 1426802-50-7 5mg $151 2024-03-01 Buy
Cayman Chemical 9002444 GSK805 ≥98% 1426802-50-7 10mg $235 2024-03-01 Buy
ChemScene CS-5079 GSK805 97.14% 1426802-50-7 10mg $280 2021-12-16 Buy
AK Scientific 2948DU RORgamma-t-IN-1 1426802-50-7 10mg $360 2021-12-16 Buy
Product number Packaging Price Buy
9002444 1mg $44 Buy
9002444 5mg $151 Buy
9002444 10mg $235 Buy
CS-5079 10mg $280 Buy
2948DU 10mg $360 Buy

ROR gamma-t-IN-1 Chemical Properties,Uses,Production

Description

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.

ROR gamma-t-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

ROR gamma-t-IN-1 Suppliers

Global( 50)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10522 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19994 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Chemtour Biotech Co., Ltd 		+8617327281506 market@chemtour.com China 1460 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
Struchem Co., Ltd. 0512-0512-63009836 15365350169 helen@struchem.com China 3988 60
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Labnetwork lnc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Chemtour Biotech Co., Ltd 		58
Amadis Chemical Company Limited 		58
Haoyuan Chemexpress Co., Ltd. 61
Struchem Co., Ltd. 60

1426802-50-7(ROR gamma-t-IN-1)Related Search:

GSK8612 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol 1-(1-(3-methoxyphenyl)-7-propoxyindolizin-3-yl)ethanone GSK8612 GSK6853
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid GSK620 GSK591 GSK5959 GSK872

1of2

ROR gamma-t-IN-1 GSK805 GSK805 (GSK-805) N-(2,6-dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one Benzeneacetamide, N-[2,6-dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)- N-[2,6-Dichloro-2'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-4-(ethylsulfonyl)benzeneacetamide N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide GSK805,N-(2,6-Dichloro-2'-(trifluoromethoxy)biphenyl-4-yl)- N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide GSK 805,immunity,RAR-related orphan receptor,Inhibitor,GSK805,inhibit,ROR,oral,CNS penetrant,GSK-805,Th17 cell N-(2,6-dichloro-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 1426802-50-7 C23H18Cl2F3NO4S