3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
- CAS No.
- 913830-15-6
- Chemical Name:
- 3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile
- Synonyms
- NS 9283;NS-9283;NS9283;NS 9283;NS-9283;NS9283;3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile;3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile;Benzonitrile, 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-;NS9283,Inhibitor,Nicotinic acetylcholine receptors,nAChR,inhibit
- CBNumber:
- CB13049683
- Molecular Formula:
- C14H8N4O
- Molecular Weight:
- 248.24
- MDL Number:
- MFCD26390306
- MOL File:
- 913830-15-6.mol
| Boiling point | 469.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: Partially soluble |
| form | A crystalline solid |
| pka | 1.40±0.12(Predicted) |
| color | White to off-white |
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29189 | NS 9283 | 913830-15-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29189 | NS 9283 | 913830-15-6 | 25mg | $420 | 2024-03-01 | Buy |
| Cayman Chemical | 29189 | NS 9283 | 913830-15-6 | 5mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 29189 | NS 9283 | 913830-15-6 | 10mg | $184 | 2024-03-01 | Buy |
| Tocris | 5112 | NS9283 ≥99%(HPLC) | 913830-15-6 | 10 | $201 | 2021-12-16 | Buy |
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Chemical Properties,Uses,Production
Description
NS 9283 is a positive allosteric modulator of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs (EC50 = 4 μM). In vivo, NS 9283 potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.
Uses
NS 9283 is a positive allosteric modulator of α4β2 receptor affecting the potency of acetylcholine (Ach) related events. This has been linked to affect on everyday brain function including cognitive function and pain alleviation.
storage
Store at +4°C
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)benzonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| D&C Chemicals | +86-21-58447131 | 1724405207@qq.com | China | 472 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1720 | 58 |