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Nonapeptide-1

Nonapeptide-1 structure

CAS No.: 158563-45-2

Chemical Name:: Nonapeptide-1

Synonyms: melanostatine;Melanostatine-5;Melitan;Neptide-1;ArkTide N91;Jiupeptide-1;NONAPEPTIDE-1;Metanostatine-5;Melitane / Nonapeptide-1;hexapeptide-2/Dermostatyl

CBNumber:: CB13052001

Molecular Formula:: C61H87N15O9S

Molecular Weight:: 1206.5

MDL Number:: MFCD00672435

MOL File:: 158563-45-2.mol

Last updated:2025-04-17 18:45:41

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Nonapeptide-1 Properties

Density	1.38±0.1 g/cm3(Predicted)
solubility	soluble in water(≥0.1g/ml)
form	Solid
pka	13.32±0.46(Predicted)
color	white or off-white powder
InChIKey	KNFLNGRLKALWRF-LDXSYGEZSA-N
FDA UNII	64W45420K5

Nonapeptide-1 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biorbyt Ltd	orb372551	Melanostatine-5 > 95%	158563-45-2	1mg	$287.3	2021-12-16	Buy
Biorbyt Ltd	orb372551	Melanostatine-5 > 95%	158563-45-2	5mg	$552.5	2021-12-16	Buy
Biorbyt Ltd	orb372551	Melanostatine-5 > 95%	158563-45-2	10mg	$708.9	2021-12-16	Buy
Chemenu	CM100718	Nonapeptide-1 97%	158563-45-2	1g	$355	2021-12-16	Buy
Crysdot	CD22004464	H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 97%	158563-45-2	1g	$376	2021-12-16	Buy

Product number	Packaging	Price	Buy
orb372551	1mg	$287.3	Buy
orb372551	5mg	$552.5	Buy
orb372551	10mg	$708.9	Buy
CM100718	1g	$355	Buy
CD22004464	1g	$376	Buy

Nonapeptide-1 Chemical Properties,Uses,Production

Description

Nonapeptide-1 is a skin lightening peptide, derived from the melanocyte stimulating hormone (MSH). It prevents the activity of tyrosine in the melanocytes, melanin synthesis inhibition and helps to even out your skin tone by lessening hyper-pigmentation. This process reduces the formation of unwanted pigmentation, allowing for the control over skin tone and brown spots.

Uses

A skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

Application

skin radiance, skin Lightening-whitening, anti-dark spot

Definition

Nonapeptide-1 is one skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

benefits

Nonapeptide-1inhibits melanin production originally induced bya-MSH.Whitening, spot-removing as well as preventing hyperpigmentation.Its recommended dosage in skin care products is 0.5~3%.

Biological Functions

1. Inhibit melanin synthesis by interfering with the action of tyrosinase in melanocytes. Reduce hyperpigmentation and lighten darker areas that have been damaged by the sun and certain diseases.2. Interfer with melanocyte stimulating hormone (MSH). MSH increases during pregnancy, as a result of certain medical conditions (e.g. diabetes, Addison’s disease), and as a result of excessive sun exposure.3. Nonapeptide-1, at a concentration of 200 ug/mL, is capable of fully inhibiting the synthesis of melanin in fungi.4. At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can reduce the melanin content of melanocytes by 27-43%

Biotechnological Applications

Nonapeptide-1 acetate salt, a peptide hormone, is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist, with an IC50 of 11 nM. Reduces synthesis of melanin and helps decrease skin pigmentation to a substantial degree[1].

Side effects

May cause drowsiness, dizziness, hypotension, or a headache as side-effects when using Nonapeptide-1 Topical medicine. Patients not drink alcohol with medicines as alcohol intensifies drowsiness side-effects.

storage

Common storage 2-8℃, long time storage -20℃.

Nonapeptide-1 Preparation Products And Raw materials

Raw materials

Preparation Products

Nonapeptide-1 Suppliers

Global( 306)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
Xinxiang Hongqi District Houyuan Trading Co.,Ltd	+86-0373-3695376 +86-13937349994	HYJM@houyuanjm.com	China	299	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5221	58
Forest chemical technology	+85295407470	grant@forestchem.freeqiye.com	China	737	58
Sichuan Jisheng Biopharmaceutical	+86-0833-2598903 +8619981963231	jane@jsjpharm.cn	China	173	58
BJV BIOTECH LTD	+86-0755-23089946 +8619006605307	bjvbiotech@163.com	China	67	58
Zhangzhou Sinobioway Peptide Co.,Ltd.	15659861111	SINOPEPT@GMAIL.COM	China	44	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12809	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7906	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	264	58

Supplier	Advantage
Cellmano Biotech Limited	58
Xinxiang Hongqi District Houyuan Trading Co.,Ltd	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
Forest chemical technology	58
Sichuan Jisheng Biopharmaceutical	58
BJV BIOTECH LTD	58
Zhangzhou Sinobioway Peptide Co.,Ltd.	58
Hebei Mujin Biotechnology Co.,Ltd	58
Shanghai UCHEM Inc.	58
Shanghai Yunao International Trade Co., Ltd	58

Nonapeptide-1 + EGCG: Reverses skin photoaging
Nonapeptide-1 is a synthetic whitening ingredient with the sequence Arg-Arg-Asp-Ser-Tyr-Pro-Tyr-Arg-Gly.
Feb 27，2025

Nonapeptide-1: Applications in Skin Care and its Preparation Method
Nonapeptide-1, a synthetic peptide that inhibits alpha-melanocyte-stimulating hormone, effectively lightens sunspots and is ef....
Sep 2，2024

View Lastest Price from Nonapeptide-1 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-27	Nonapeptide-1 158563-45-2	US $0.00-0.00 / Kg	1Kg	99.99%	20 tons	Chongqing Soarwin Technology Co., Ltd
2025-04-27	Nonapeptide-1 158563-45-2	US $0.00-0.00 / G	1G	99%	1 ton/year	Forest chemical technology
2025-04-27	Nonapeptide-1 158563-45-2	US $0.00-0.00 / kg	1kg	99%	500	Wuhan Haorong Biotechnology Co.,Ltd

Nonapeptide-1
158563-45-2
US $0.00-0.00 / Kg
99.99%
Chongqing Soarwin Technology Co., Ltd

Nonapeptide-1
158563-45-2
US $0.00-0.00 / G
99%
Forest chemical technology

Nonapeptide-1
158563-45-2
US $0.00-0.00 / kg
99%
Wuhan Haorong Biotechnology Co.,Ltd

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1of4

L-Methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide Melanostatine-5(nonpeptide-1) Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂ Melitane / Nonapeptide-1 Melanostatine-5, Nonapeptide-1 NONAPEPTIDE-1 Nonapeptide-1, Melanostatine-5, Melanostatine Melitan Nonapeptide-1/Melitane/Melanostatine Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val- L-Valinamide, L-methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl- Cosmetics peptide Nonapeptide-1 powder Nonapeptide-1(Melanostatine-5) Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 USP/EP/BP hexapeptide-2/Dermostatyl superior quality Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 CAS 158563-45-2 CAS 158563-45-2 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2 Melanostatine-5 melanostatine Metanostatine-5 4-Hydroxypyridine 626-64-2 (Met?,Pro?,D-Phe?,D-Trp?,Phe1?)-α-MSH (5-13) (Met?,Pro?,D-Phe?,D-Trp?,Phe??)-α-MSH (5-13) Jiupeptide-1 Neptide-1 ArkTide N91 Bright-NP (Nonapeptide-1) 158563-45-2 951-78-9 C61H87N15O9S 158563-45-2