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Pamiparib

Pamiparib structure

CAS No.: 1446261-44-4

Chemical Name:: Pamiparib

Synonyms: Pamiparib;bgb-290;EOS-61090;Pamiparib(BGB290);BGB-290,Pamiparib;Alflutinib Impurity 17;PAMIPARIB; BGB-290; BGB 290; BGB290.;inhibit,Pamiparib,PARP,Inhibitor,poly ADP ribose polymerase,BGB 290,BGB290;(R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one;(R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one

CBNumber:: CB13137483

Molecular Formula:: C16H15FN4O

Molecular Weight:: 298.31

MDL Number:: MFCD30489383

MOL File:: 1446261-44-4.mol

Last updated:2024-11-06 15:28:16

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Pamiparib Properties

Density	1.68±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF:20.0(Max Conc. mg/mL);67.04(Max Conc. mM) DMF:PBS (pH 7.2) (1:10):0.09(Max Conc. mg/mL);0.3(Max Conc. mM) DMSO:40.83(Max Conc. mg/mL);136.88(Max Conc. mM) Ethanol:45.0(Max Conc. mg/mL);150.84(Max Conc. mM)
form	A solid
pka	11.56±0.40(Predicted)
color	Light yellow to yellow
FDA UNII	8375F9S90C
NCI Drug Dictionary	pamiparib

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06,GHS02

Signal word

Danger

Hazard statements

H300+H310+H330-H314-H226

Precautionary statements

P501-P260-P270-P262-P240-P210-P233-P243-P241-P242-P271-P264-P280-P284-P370+P378-P361+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405

NFPA 704

	0
2		0

Pamiparib price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0027388	Pamiparib 99.97%	1446261-44-4	5mg	$90	2021-12-16	Buy
ChemScene	CS-0027388	Pamiparib 99.97%	1446261-44-4	10mg	$150	2021-12-16	Buy
ChemScene	CS-0027388	Pamiparib 99.97%	1446261-44-4	25mg	$250	2021-12-16	Buy
ChemScene	CS-0027388	Pamiparib 99.97%	1446261-44-4	50mg	$450	2021-12-16	Buy
ChemScene	CS-0027388	Pamiparib 99.97%	1446261-44-4	100mg	$750	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0027388	5mg	$90	Buy
CS-0027388	10mg	$150	Buy
CS-0027388	25mg	$250	Buy
CS-0027388	50mg	$450	Buy
CS-0027388	100mg	$750	Buy

Pamiparib Chemical Properties,Uses,Production

Description

Pamiparib (BGB-290) is an investigational small molecule inhibitor of PARP1 and PARP2. Pamiparib is being evaluated as a monotherapy in pivotal clinical trials in China in recurrent platinum-sensitive and BRCA1/2 mutated ovarian cancers.

Uses

Pamiparib, is a PARP inhibitor, which can be used as an anticancer agent.

in vivo

Oral administration of Pamiparib results in time-dependent and dose-dependent inhibition of PARylation in MDA-MB-436 (BRCA1 mutant) breast cancer xenograft, correlating well with the tumor drug concentrations. It has also demonstrated good combination activity with chemotherapeutics in patient biopsy derived SCLC models. Also Pamiparib has significant brain penetration in C57 mice. The drug exposure in brain vs. that in plasma was close to 20% after oral administration of BGB-290.

Pamiparib synthesis

Synthesis of Pamiparib from D-Proline

Pamiparib Preparation Products And Raw materials

Raw materials

(3S,7aR)-3-(trichloroMethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one methyl 3-amino-2-bromo-5-fluorobenzoate (R)-methyl 9-fluoro-11b-methyl-6-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-7-carboxylate 2-Methyl-1-pyrroline D-Proline

Preparation Products

Pamiparib Suppliers

Global( 80)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32070	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38463	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shenzhen Shengda Pharma Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from Pamiparib manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-06	Pamiparib 1446261-44-4	US $30.00-50.00 / mg		99.53%	10g	TargetMol Chemicals Inc.

Pamiparib
1446261-44-4
US $30.00-50.00 / mg
99.53%
TargetMol Chemicals Inc.

(R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one (R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)- PAMIPARIB; BGB-290; BGB 290; BGB290. BGB-290,Pamiparib Pamiparib(BGB290) EOS-61090 bgb-290 Pamiparib inhibit,Pamiparib,PARP,Inhibitor,poly ADP ribose polymerase,BGB 290,BGB290 (2R)-14-fluoro-2-methyl-6,9,10,19-tetraazapentacyclo[14.2.1.02,?.0?,1?.012,1?]nonadeca-1(18),8,12(17),13,15-pentaen-11-one Alflutinib Impurity 17 1446261-44-4 1446261-44-1 APIS