ChemicalBook >> CAS DataBase List >>SYP-5
SYP-5
- CAS No.
- 1384268-04-5
- Chemical Name:
- SYP-5
- Synonyms
- SYP-5;SYP5; SYP 5;SYP-5 >=98% (HPLC);(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-;SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase
- CBNumber:
- CB13145907
- Molecular Formula:
- C18H16O3S
- Molecular Weight:
- 312.38
- MDL Number:
- MFCD30534394
- MOL File:
- 1384268-04-5.mol
Last updated:2024-07-02 08:55:00
Boiling point | 502.0±50.0 °C(Predicted) |
---|---|
Density | 1.263±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility |
DMF:30.0(Max Conc. mg/mL);96.04(Max Conc. mM) DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.96(Max Conc. mM) DMSO:25.0(Max Conc. mg/mL);80.03(Max Conc. mM) Ethanol:1.0(Max Conc. mg/mL);3.2(Max Conc. mM) |
form | A solid |
pka | 7.12±0.40(Predicted) |
color | Yellow to orange |
SYP-5 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-6108 | SYP-5 99.68% | 1384268-04-5 | 5mg | $70 | 2021-12-16 | Buy |
ChemScene | CS-6108 | SYP-5 99.68% | 1384268-04-5 | 10mg | $120 | 2021-12-16 | Buy |
ChemScene | CS-6108 | SYP-5 99.68% | 1384268-04-5 | 50mg | $490 | 2021-12-16 | Buy |
ChemScene | CS-6108 | SYP-5 99.68% | 1384268-04-5 | 100mg | $900 | 2021-12-16 | Buy |
DC Chemicals | DC10436 | SYP-5 >98% | 1384268-04-5 | 250mg | $1250 | 2021-12-16 | Buy |
SYP-5 Chemical Properties,Uses,Production
Biological Activity
SYP-5, an inhibitor of Hypoxia-inducible factor-1 (HIF-1), inhibits tumor cell migration and invasion and tumor angiogenesis.
in vitro
SYP-5 inhibits hypoxia-induced upregulation of HIF-1. It inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. It inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down -regulated by SYP-5.
target
Target | Value |
HIF-1 () |
SYP-5 Preparation Products And Raw materials
Raw materials
Preparation Products
SYP-5 Suppliers
Global( 43)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4309 | 55 | |
Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 396 | 55 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
SYP-5
SYP5; SYP 5
2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(2-thienyl)-, (2E)-
SYP-5 >=98% (HPLC)
SYP-5,Inhibitor,HIFs,Hypoxia-inducible factors,SYP5,inhibit,HIF-PH,SYP 5,HIF/HIF Prolyl-Hydroxylase
(E)-1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(thiophen-2-yl)prop-2-en-1-one
1384268-04-5