ChemicalBook >> CAS DataBase List >>3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid

3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid

3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid structure

CAS No.: 1143579-78-5

Chemical Name:: 3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid

Synonyms: II-B08;3-(1-(3-([1;II B08,IIB08;FAP1 Inhibitor;LMWPTP Inhibitor;CD45 Inhibitor V;Lyp Inhibitor III;1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1;3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid;3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid

CBNumber:: CB13146904

Molecular Formula:: C33H27N5O4

Molecular Weight:: 557.59858

MDL Number:: MFCD32645102

MOL File:: 1143579-78-5.mol

Last updated:2024-10-28 16:48:35

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3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid Properties

Density	1.34±0.1 g/cm3(Predicted)
pka	2.91±0.30(Predicted)

3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid Chemical Properties,Uses,Production

Description

II-B08, also known as PTP Inhibitor XXXI, is a cell-permeable SHP2 inhibitor (IC50 = 5.5 μM). II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation, providing supporting evidence that chemical inhibition of SHP2 may be therapeutically useful for anticancer and antileukemia treatment. X-ray crystallographic analysis of the structure of SHP2 in complex with 9 reveals molecular determinants that can be exploited for the acquisition of more potent and selective SHP2 inhibitors.

3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid synthesis

Synthesis of 3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy- and Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Feibo Pharm Technology Co., Ltd	15982321820	abby@arkpharm.com	CHINA	3274	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32002	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19863	58
Chengdu Feibai Pharmaceutical Co., Ltd.	028-84641798 18782128315	3302391190@qq.com	China	9108	55
Xi'an Minze Pharmaceutical Technology Co., Ltd	13981836672	2560370848@qq.com	China	2807	58
Absin Bioscience Inc.	021-38015121 15000105423	wulan@absin.cn	China	24731	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19699	58

Supplier	Advantage
Chengdu Feibo Pharm Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Chengdu Feibai Pharmaceutical Co., Ltd.	55
Xi'an Minze Pharmaceutical Technology Co., Ltd	58
Absin Bioscience Inc.	58
TargetMol Chemicals Inc.	58

View Lastest Price from 3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-28	II-B08 1143579-78-5	US $2780.00-3700.00 / mg			10g	TargetMol Chemicals Inc.

II-B08
1143579-78-5
US $2780.00-3700.00 / mg
TargetMol Chemicals Inc.

3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid II-B08 1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1 3-(1-(3-([1 3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid CD45 Inhibitor V FAP1 Inhibitor LMWPTP Inhibitor Lyp Inhibitor III II B08,IIB08 1H-Indole-5-carboxylic acid, 3-[1-[3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl]-6-hydroxy-1-methyl-2-phenyl- 3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid 1143579-78-5