ChemicalBook >> CAS DataBase List >>3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
- CAS No.
- 1143579-78-5
- Chemical Name:
- 3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
- Synonyms
- II-B08;3-(1-(3-([1;II B08,IIB08;FAP1 Inhibitor;LMWPTP Inhibitor;CD45 Inhibitor V;Lyp Inhibitor III;1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1;3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid;3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
- CBNumber:
- CB13146904
- Molecular Formula:
- C33H27N5O4
- Molecular Weight:
- 557.59858
- MDL Number:
- MFCD32645102
- MOL File:
- 1143579-78-5.mol
Last updated:2024-10-28 16:48:35
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid Chemical Properties,Uses,Production
Description
II-B08, also known as PTP Inhibitor XXXI, is a cell-permeable SHP2 inhibitor (IC50 = 5.5 μM). II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation, providing supporting evidence that chemical inhibition of SHP2 may be therapeutically useful for anticancer and antileukemia treatment. X-ray crystallographic analysis of the structure of SHP2 in complex with 9 reveals molecular determinants that can be exploited for the acquisition of more potent and selective SHP2 inhibitors.
Synthesis of 3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy- and Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid Suppliers
Global( 8)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3274 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32002 | 58 |
TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19863 | 58 |
Chengdu Feibai Pharmaceutical Co., Ltd. | 028-84641798 18782128315 | 3302391190@qq.com | China | 9108 | 55 |
Xi'an Minze Pharmaceutical Technology Co., Ltd | 13981836672 | 2560370848@qq.com | China | 2807 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24731 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
View Lastest Price from 3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid manufacturers
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
II-B08
1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1
3-(1-(3-([1
3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
CD45 Inhibitor V
FAP1 Inhibitor
LMWPTP Inhibitor
Lyp Inhibitor III
II B08,IIB08
1H-Indole-5-carboxylic acid, 3-[1-[3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl]-6-hydroxy-1-methyl-2-phenyl-
3-(1-(3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
1143579-78-5