Sodium phosphate dibasic dodecahydrate
- CAS No.
- 10039-32-4
- Chemical Name:
- Sodium phosphate dibasic dodecahydrate
- Synonyms
- DISODIUM HYDROGEN PHOSPHATE;DISODIUM PHOSPHATE DODECAHYDRATE;dodecahydrate;SODIUM MONOHYDROGEN PHOSPHATE;Dibasic Sodium Phosphate Dodecahydrate;Dibasic Sodium Phosphate Hydrate;DI-SODIUM HYDROGEN PHOSPHATE DODECAHYDRATE;lisnuanerqingna;DISODIUM PHOSPHATE (DSP);SODIUM PFAT 2BAS 12HYD XTL
- CBNumber:
- CB1324215
- Molecular Formula:
- H25Na2O16P
- Molecular Weight:
- 358.14
- MDL Number:
- MFCD00149181
- MOL File:
- 10039-32-4.mol
- MSDS File:
- SDS
| Melting point | 35 °C |
|---|---|
| Density | 1,52 g/cm3 |
| storage temp. | Store at +15°C to +25°C. |
| solubility | H2O: 0.1 M at 20 °C, clear, colorless |
| form | Crystals |
| color | White |
| PH | 9.0-9.3 (25℃, 50mg/mL in H2O) |
| Odor | Odorless |
| PH Range | 8.4 - 9.6 at 36 g/l at 25 °C |
| Water Solubility | 218 g/L (20 ºC) |
| λmax |
λ: 260 nm Amax: 0.01 λ: 280 nm Amax: 0.01 |
| InChI | InChI=1S/2Na.H3O4P.12H2O/c;;1-5(2,3)4;;;;;;;;;;;;/h;;(H3,1,2,3,4);12*1H2/q2*+1;;;;;;;;;;;;;/p-2 |
| InChIKey | DGLRDKLJZLEJCY-UHFFFAOYSA-L |
| SMILES | P([O-])([O-])(=O)O.O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+] |
| FDA 21 CFR | 175.210; 175.300; 181.29 |
| CAS DataBase Reference | 10039-32-4(CAS DataBase Reference) |
| FDA UNII | E1W4N241FO |
| EPA Substance Registry System | Disodium phosphate dodecahydrate (10039-32-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305+P351+P338 |
| Safety Statements | 24/25 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 1 |
| RTECS | TC5725000 |
| HS Code | 28352200 |
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
Sodium phosphate dibasic dodecahydrate price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1.06579 | di-Sodium hydrogen phosphate dodecahydrate for analysis EMSURE? ISO,Reag. Ph Eur | 10039-32-4 | 500g | $57.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1.06579 | di-Sodium hydrogen phosphate dodecahydrate for analysis EMSURE? ISO,Reag. Ph Eur | 10039-32-4 | 1kg | $88.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1.06579 | di-Sodium hydrogen phosphate dodecahydrate for analysis EMSURE? ISO,Reag. Ph Eur | 10039-32-4 | 5kg | $311 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1.06573 | di-Sodium hydrogen phosphate dodecahydrate cryst., Emprove? Essential, Ph. Eur., BP, ChP, JP, USP | 10039-32-4 | 1kg | $56 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1.06579 | di-Sodium hydrogen phosphate dodecahydrate for analysis EMSURE? ISO,Reag. Ph Eur | 10039-32-4 | 25kg | $1780 | 2024-03-01 | Buy |
Sodium phosphate dibasic dodecahydrate Chemical Properties,Uses,Production
Chemical Properties
The USP 32 states that dibasic sodium phosphate is dried or
contains, 1, 2, 7, or 12 molecules of water of hydration.
Anhydrous dibasic sodium phosphate occurs as a white powder.
The dihydrate occurs as white or almost white, odorless crystals.
The heptahydrate occurs as colorless crystals or as a white granular
or caked salt that effloresces in warm, dry air. The dodecahydrate
occurs as strongly efflorescent, colorless or transparent crystals.
Chemical Properties
white crystals
Uses
Sodium Phosphate Dibasic Dodecahydrate is used in method for preparing self-supporting membrane.
Uses
Laxative.
Production Methods
Either bone phosphate (bone ash), obtained by heating bones to
whiteness, or the mineral phosphorite is used as a source of tribasic
calcium phosphate, which is the starting material in the industrial
production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with
sulfuric acid. This mixture is then leached with hot water and
neutralized with sodium carbonate, and dibasic sodium phosphate
is crystallized from the filtrate.
Definition
ChEBI: A hydrate that is the dodecahydrate form of disodium hydrogenphosphate
General Description
Sodium phosphate is a colorless crystalline sodium salt. It is widely used as a buffer in molecular biology, biochemistry, and chromatographic studies. It exists in three forms: monobasic (NaH2PO4), dibasic (Na2HPO4), and tribasic (Na3PO4). Monobasic and dibasic forms in varying ratios are commonly used to compose the neutral sodium phosphate buffer solution.
Pharmaceutical Applications
Dibasic sodium phosphate is used in a wide variety of pharmaceutical
formulations as a buffering agent and as a sequestering agent.
Therapeutically, dibasic sodium phosphate is used as a mild laxative
and in the treatment of hypophosphatemia.
Dibasic sodium phosphate is also used in food products; for
example as an emulsifier in processed cheese.
Safety
Dibasic sodium phosphate is widely used as an excipient in
parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in
many physiological processes since it is the principal anion of
intracellular fluid. Most foods contain adequate amounts of
phosphate, making hypophosphatemia (phosphate deficiency)
virtually unknown except for certain disease states or in patients
receiving total parenteral nutrition. Treatment is usually by the oral
administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed
from the gastrointestinal tract, virtually all of it being excreted in the
urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously,
rectally, or in patients with renal failure, can cause
hyperphosphatemia that may lead to hypocalcemia or other severe
electrolyte imbalances. Adverse effects occur less frequently
following oral consumption, although phosphates act as mild saline
laxatives when administered orally or rectally. Consequently,
gastrointestinal disturbances including diarrhea, nausea, and
vomiting may occur following the use of dibasic sodium phosphate
as an excipient in oral formulations. However, the level of dibasic
sodium phosphate used as an excipient in a pharmaceutical
formulation is not usually associated with adverse effects.
LD50 (rat, oral): 17 g/kg
storage
The anhydrous form of dibasic sodium phosphate is hygroscopic.
When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its
water of crystallization; and at a dull-red heat (about 240℃) it is
converted into the pyrophosphate, Na4P2O7. Aqueous solutions of
dibasic sodium phosphate are stable and may be sterilized by
autoclaving.
The bulk material should be stored in an airtight container, in a
cool, dry place.
Incompatibilities
Dibasic sodium phosphate is incompatible with alkaloids, antipyrine, chloral hydrate, lead acetate, pyrogallol, resorcinol and calcium gluconate, and ciprofloxacin. Interaction between calcium and phosphate, leading to the formation of insoluble calcium-phosphate precipitates, is possible in parenteral admixtures.
Regulatory Status
GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (injections; infusions; nasal, ophthalmic, oral, otic, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Sodium phosphate dibasic dodecahydrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chuandong Chemical (Group) Co. Ltd. | +86-13637972665 +86-13637972665 | wxc@cd1958.com | China | 81 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5978 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 +86-18633929156 | admin@hblongbang.com | China | 941 | 58 |
| Hebei Andu Technology Com.,Ltd | +86-86-17798073498 +8617798073498 | admin@hbandu.com | China | 299 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
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View Lastest Price from Sodium phosphate dibasic dodecahydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-24 | Disodium Phosphate Dodecahydrate
10039-32-4
|
US $3.60 / kg | 1kg | ≥99% | 3000tons/month | Hebei Andu Technology Com.,Ltd | |
 |
2024-11-24 | Sodium phosphate dibasic dodecahydrate
10039-32-4
|
US $99.00-66.00 / kg | 0.001kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-22 | Sodium phosphate dibasic dodecahydrate
10039-32-4
|
US $0.00-0.00 / KG | 1KG | 99.5% | 20tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Disodium Phosphate Dodecahydrate
10039-32-4
- US $3.60 / kg
- ≥99%
- Hebei Andu Technology Com.,Ltd
-
- Sodium phosphate dibasic dodecahydrate
10039-32-4
- US $99.00-66.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Sodium phosphate dibasic dodecahydrate
10039-32-4
- US $0.00-0.00 / KG
- 99.5%
- WUHAN FORTUNA CHEMICAL CO., LTD
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