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GNE-8525

GNE-8525 Structure
GNE-8525 structure
CAS No.
1196546-33-4
Chemical Name:
GNE-8525
Synonyms
GNF-8625;GNE-8525;4-Piperidinol, 1-[6-[6-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl][2,4'-bipyridin]-2'-yl]-
CBNumber:
CB13313508
Molecular Formula:
C31H30FN7O
Molecular Weight:
535.61
MDL Number:
MFCD33398914
MOL File:
1196546-33-4.mol
Last updated:2024-10-28 23:16:16
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GNE-8525 Properties

Density 1.39±0.1 g/cm3(Predicted)
pka 14.70±0.20(Predicted)

GNE-8525 Chemical Properties,Uses,Production

Description

GNE-8525 is a potent and selective pan-TRK inhibitor. GNE-8525 demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats. Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA have been reported in colorectal, papillary thyroid, glioblastoma, melanoma, and lung tissue that are believed to be the key oncogenic driver in these tumors.

GNE-8525 Preparation Products And Raw materials

Raw materials

Preparation Products

GNE-8525 Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19863 58
Shanghai PharmaPartner Co., Ltd. 13621689085 pharmabridge@163.com China 504 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19711 58
Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Shanghai PharmaPartner Co., Ltd. 55
TargetMol Chemicals Inc. 58

View Lastest Price from GNE-8525 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GNF-8625 pictures 2024-10-28 GNF-8625
1196546-33-4
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • GNF-8625 pictures
  • GNF-8625
    1196546-33-4
  • US $2500.00-1520.00 / mg
  • TargetMol Chemicals Inc.
GNE-8525 GNF-8625 4-Piperidinol, 1-[6-[6-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl][2,4'-bipyridin]-2'-yl]- 1196546-33-4