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Val-Ala-PAB

Val-Ala-PAB Structure
Val-Ala-PAB structure
CAS No.
1343476-44-7
Chemical Name:
Val-Ala-PAB
Synonyms
Val-Ala-PAB-OH;(S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide;CS-2747;Val-Ala-PAB;H-Val-Ala-PAB;Val Ala PAB,ValAlaPAB;L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]-;(2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide;(S)-2-Amino-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide
CBNumber:
CB13364146
Molecular Formula:
C15H23N3O3
Molecular Weight:
293.36
MDL Number:
MFCD32641649
MOL File:
1343476-44-7.mol
Last updated:2024-03-29 18:52:01
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Val-Ala-PAB Properties

Melting point 65-68°C
Boiling point 584.9±50.0 °C(Predicted)
Density 1.191±0.06 g/cm3(Predicted)
storage temp. -20°C, Inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka 13.51±0.70(Predicted)
form Solid
color White to Off-White

Val-Ala-PAB price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC V091550 Val-Ala-PAB 1343476-44-7 1g $1210 2021-12-16 Buy
TRC V091550 Val-Ala-PAB 1343476-44-7 5g $4400 2021-12-16 Buy
TRC V091550 Val-Ala-PAB 1343476-44-7 25g $18700 2021-12-16 Buy
Ambeed A1492902 (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide 97% 1343476-44-7 50mg $163 2021-12-16 Buy
Ambeed A1492902 (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide 97% 1343476-44-7 100mg $249 2021-12-16 Buy
Product number Packaging Price Buy
V091550 1g $1210 Buy
V091550 5g $4400 Buy
V091550 25g $18700 Buy
A1492902 50mg $163 Buy
A1492902 100mg $249 Buy

Val-Ala-PAB Chemical Properties,Uses,Production

Description

Val-Ala-PAB-OH is a cleavable ADC linker with a terminal hydroxyl group. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.

Val-Ala-PAB Preparation Products And Raw materials

Raw materials

Preparation Products

Val-Ala-PAB Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9425 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		+8618235132063 sales@tihondan.com China 3725 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2996 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4692 58
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. 13414494621 chenchao02lzu@126.com China 116 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13913916777 info@chemlin.com.cn China 18070 64
Tianjin Chempharmatech Co.,Ltd. 022-66211079 13212288319 sales@chempharmatech.com China 827 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Henan Aochuang Chemical Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Xian confluore Biological Technology Co., Ltd. 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. 58
Nanjing Chemlin Chemical Co., Ltd 64
Tianjin Chempharmatech Co.,Ltd. 55

View Lastest Price from Val-Ala-PAB manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Val-Ala-PAB-OH pictures 2024-03-29 Val-Ala-PAB-OH
1343476-44-7
 US $0.00 / g 1g >95.00% 1g Xian confluore Biological Technology Co., Ltd.
  • Val-Ala-PAB-OH pictures
  • Val-Ala-PAB-OH
    1343476-44-7
  • US $0.00 / g
  • >95.00%
  • Xian confluore Biological Technology Co., Ltd.

Val-Ala-PAB Spectrum

Val-Ala-PAB(1343476-44-7)1HNMR
Val-Ala-PAB CS-2747 (2S)-2-amino-N-[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]-3-methylbutanamide L-Alaninamide, L-valyl-N-[4-(hydroxymethyl)phenyl]- Val-Ala-PAB-OH (S)-2-Amino-N-((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)-3-methylbutanamide Val Ala PAB,ValAlaPAB H-Val-Ala-PAB (S)-2-Amino-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide 1343476-44-7 Linker