Betamethasone 21-acetate
- CAS No.
- 987-24-6
- Chemical Name:
- Betamethasone 21-acetate
- Synonyms
- BETAMETHASONE ACETATE;Betamethasone 21-ace;BETAMETHASONE 21-ACETATE;Betamethasone 21-Acetata;Betamethasone acetate CRS;Betamethasone Acetate API;Betamethasone21-acetatemicro;Betamethasone-21 acetate salt;Betamethasone Acetate (500 mg);C10575005 BetamethasonEacetate
- CBNumber:
- CB1337284
- Molecular Formula:
- C24H31FO6
- Molecular Weight:
- 434.5
- MDL Number:
- MFCD00867462
- MOL File:
- 987-24-6.mol
- MSDS File:
- SDS
| Melting point | 200-220°C (dec.) |
|---|---|
| alpha | D +140° (chloroform) |
| Boiling point | 579.4±50.0 °C(Predicted) |
| Density | 1.0932 (rough estimate) |
| refractive index | 1.5980 (estimate) |
| storage temp. | Refrigerator |
| solubility | Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9). |
| form | Solid |
| pka | 12.08±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | 30mg/L(25 ºC) |
| Merck | 14,1180 |
| CAS DataBase Reference | 987-24-6(CAS DataBase Reference) |
| FDA UNII | TI05AO53L7 |
| EPA Substance Registry System | .beta.-Methasone acetate (987-24-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H373 |
| Precautionary statements | P202-P260-P280-P308+P313-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 40 |
| Safety Statements | 22-36 |
| WGK Germany | 3 |
| HS Code | 2937220000 |
Betamethasone 21-acetate price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1779 | Betamethasone acetate Pharmaceutical Secondary Standard; Certified Reference Material | 987-24-6 | 1g | $267 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1067001 | Betamethasone acetate United States Pharmacopeia (USP) Reference Standard | 987-24-6 | 500mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | B1030000 | Betamethasone acetate European Pharmacopoeia (EP) Reference Standard | 987-24-6 | b1030000 | $220 | 2024-03-01 | Buy |
| TRC | B327025 | Betamethasone21-Acetate | 987-24-6 | 1g | $1185 | 2021-12-16 | Buy |
| TRC | B327025 | Betamethasone21-Acetate | 987-24-6 | 5mg | $95 | 2021-12-16 | Buy |
Betamethasone 21-acetate Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Celestone Soluspan,Schering,US,1965
Uses
CORTICOSTEROID
Uses
amino acid, nutrient
Uses
Betamethasone acetate (BA)
Definition
ChEBI: Betamethasone acetate is an acetate ester, a steroid ester, a fluorinated steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, an 11beta-hydroxy steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a betamethasone.
Manufacturing Process
The synthesis is long and complex. For brevity, only the last steps are given
here. Refer to the patents cited below for full details.
Preparation of 9α-Bromo-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20-
Dione 21-Acetate: To a mixture of 620 mg of 17α,21-dihydroxy-16β-methyl-
4,9(11)-pregnadiene-3,20-dione 21-acetate and 330 mg of Nbromosuccinimide in 10 ml of dioxane and 3.2 ml of water cooled to 10°C was
added 1.8 ml of cold 1 M aqueous perchloric acid. The mixture was stirred at
15°C for 3 hours. Excess N-bromosuccinimide was destroyed by addition of
aqueous sodium thiosulfate and most of the dioxane was removed in vacuo.
About 30 ml of water was added and crystalline bromohydrin, 9α-bromo-
11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate, was filtered, washed with water, and dried in air.
Preparation of 9β,11β-Epoxy-17α-21-Dihydroxy-16β-Methyl-4-Pregnene-3,20-
Dione 21-Acetate: To a stirred solution of 100 mg of the 9α-bromo-
11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate in 3 ml
of tetrahydrofuran and 1 ml of methanol under nitrogen was added 1.02 ml of
0.215N methanolic sodium methoxide. After 10 minutes at 25°C, 0.2 ml of
acetic acid was added and the methanol removed in vacuo. The residue was
acetylated with 1.00 ml of pyridine and 0.5 ml of acetic anhydride at 60°C for
70 minutes. The mixture was taken to dryness in vacuo, water added, and the
product extracted into chloroform. The residue was crystallized from etheracetone to give pure 9β,11β-epoxy-17α,21-dihydroxy-16β-methyl-4-pregnene-
3,20-dione 21-acetate.
Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnene-3,20-
Dione 21-Acetate: To a solution of 200 mg of 9β,11β-epoxy-17α,21-dihydroxy-
16β-methyl-4-pregnene-3,20-dione 21-acetate in 2 ml of chloroform and 2 ml
of tetrahydrofuran in a polyethylene bottle at -60°C was added 2 ml of a 2:1
(by weight) mixture of anhydrous hydrogen fluoride and tetrahydrofuran. After
4 hours at -10°C the mixture was cooled to -60°C and cautiously added to a
stirred mixture of 30 ml or 25% aqueous potassium carbonate and 25 ml of
chloroform kept at -5°C. The aqueous phase was further extracted with
chloroform and the latter phase washed with water and dried over magnesium
sulfate. The residue on crystallization from acetone-ether gave pure 9α-fluoro-
11β,17α,21-trihydroxy-16β-methyl-4-pregnene-3,20-dione 21-acetate.
Preparation of 9α-Fluoro-11β,17α,21-Trihydroxy-16β-Methyl-4-Pregnadiene-
3,20-Dione 21-Acetate 100 mg of 9α-fluoro-11β,17α,21-trihydroxy-16β-
methyl-4-pregnene-3,20-dione 21-acetate was treated with selenium dioxide
to produce the corresponding 9α-fluoro-11β,17α,21-trihydroxy-16β-methyl-4-
pregnadiene-3,20-dione 21-acetate. Alternately, Bacillus sphaericus may be
utilized.
Therapeutic Function
Glucocorticoid
Betamethasone 21-acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12806 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 307 | 58 |
| Hebei Junhua Import and Export Co., LTD | +86-18503288844 +86-18503288844 | junhua1@hb-junhua.com | China | 978 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19843 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6383 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
View Lastest Price from Betamethasone 21-acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | Betamethasone 21-acetate
987-24-6
|
US $0.00 / kg | 1kg | 98% | 1000 | Hebei Junhua Import and Export Co., LTD | |
 |
2025-04-27 | Betamethasone 21-acetate/Betamethasone Acetate
987-24-6
|
US $0.00-0.00 / KG | 1KG | 99% | 5000 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2025-04-23 | Betamethasone 21-acetate
987-24-6
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Betamethasone 21-acetate
987-24-6
- US $0.00 / kg
- 98%
- Hebei Junhua Import and Export Co., LTD
-
- Betamethasone 21-acetate/Betamethasone Acetate
987-24-6
- US $0.00-0.00 / KG
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
-
- Betamethasone 21-acetate
987-24-6
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd