ChemicalBook >> CAS DataBase List >>N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
![N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Structure](CAS/20180528/GIF/1627138-52-6.gif)
- CAS No.
- 1627138-52-6
- Chemical Name:
- N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
- Synonyms
- ML380;1-((1H-Indazol-5-yl)sulfonyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide;N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide;4-Piperidinecarboxamide, N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]-;positive,ML380,Muscarinic acetylcholine receptor,allosteric,inhibit,ACh,modulator,Inhibitor,mAChR,PAM
- CBNumber:
- CB13414100
- Molecular Formula:
- C23H25F3N4O3S
- Molecular Weight:
- 494.53
- MDL Number:
- MFCD28386214
- MOL File:
- 1627138-52-6.mol
Last updated:2024-11-09 19:38:33
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Properties
| Boiling point | 661.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.388±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 100 mg/mL (202.21 mM) |
| form | Solid |
| pka | 12.84±0.40(Predicted) |
| color | White to off-white |
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0011371 | ML380 99.91% | 1627138-52-6 | 5mg | $85 | 2021-12-16 | Buy |
| ChemScene | CS-0011371 | ML380 99.91% | 1627138-52-6 | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0011371 | ML380 99.91% | 1627138-52-6 | 25mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0011371 | ML380 99.91% | 1627138-52-6 | 50mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0011371 | ML380 99.91% | 1627138-52-6 | 100mg | $750 | 2021-12-16 | Buy |
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Chemical Properties,Uses,Production
Biological Activity
ML380 is a potent, isotype-selective and blood-brain barrier-permeable positive allosteric modulator (PAM) of M5 mAChR with EC50 values of 190 and 610 nM for human and rat M5, respectively.
in vivo
ML380 (1 mg/kg; iv) displays high clearance (66 mL/min/kg), a moderate volume of distribution (1.6 L/kg), and a short half-life (t 1/2 , 22 min) in rats.
target
IC50: 190 nM (hM5), 610 nM (rM5)
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Suppliers
Global( 14)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32072 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 | sales@sun-shinechem.com | China | 977 | 64 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | Sales@ATKchemical.com | China | 7045 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 8752 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29785 | 68 |
| Wuhan Sun-shine Bio-technology Corporation Limited | +86-027-6552-2453 | sales@sun-shinechem.com | China | 727 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62163 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24648 | 58 |
View Lastest Price from N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide manufacturers
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide Spectrum
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
ML380
positive,ML380,Muscarinic acetylcholine receptor,allosteric,inhibit,ACh,modulator,Inhibitor,mAChR,PAM
4-Piperidinecarboxamide, N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]-
1-((1H-Indazol-5-yl)sulfonyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide
1627138-52-6