4'-HYDROXYCHALCONE
- CAS No.
- 2657-25-2
- Chemical Name:
- 4'-HYDROXYCHALCONE
- Synonyms
- 4'-Hydroxychalcone;HYDROXYCHALCONE, 4'-;4'-Hydroxychalcone98%;4'-Hydroxychalcone>4'-Hydroxychalcone 98%;4'-Hydroxychalcone,97%;4’-Hydroxychalcone-97%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone, ≥ 95.0%;2-BENZAL-4'-HYDROXYACETOPHENONE
- CBNumber:
- CB1342383
- Molecular Formula:
- C15H12O2
- Molecular Weight:
- 224.25
- MDL Number:
- MFCD00016484
- MOL File:
- 2657-25-2.mol
- MSDS File:
- SDS
| Melting point | 174-178 °C |
|---|---|
| Boiling point | 419.6±45.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml |
| form | powder to crystal |
| pka | 7.72±0.15(Predicted) |
| color | Light orange to Yellow to Green |
| BRN | 2049150 |
| InChIKey | UAHGNXFYLAJDIN-IZZDOVSWSA-N |
| LogP | 3.650 (est) |
| CAS DataBase Reference | 2657-25-2(CAS DataBase Reference) |
| FDA UNII | 2K338K8UOA |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-37 | |||||||||
| HS Code | 29145090 | |||||||||
| NFPA 704 |
|
4'-HYDROXYCHALCONE price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS003892 | 4′-hydroxychalcone AldrichCPR | 2657-25-2 | 250MG | $84.9 | 2024-03-01 | Buy |
| TCI Chemical | H0945 | 4'-Hydroxychalcone >95.0%(GC) | 2657-25-2 | 5g | $24 | 2024-03-01 | Buy |
| Alfa Aesar | A10838 | 4'-Hydroxychalcone, 97% | 2657-25-2 | 5g | $48.65 | 2024-03-01 | Buy |
| Alfa Aesar | A10838 | 4'-Hydroxychalcone, 97% | 2657-25-2 | 25g | $180.65 | 2024-03-01 | Buy |
| Cayman Chemical | 22898 | 4'-hydroxy Chalcone ≥98% | 2657-25-2 | 5g | $44 | 2024-03-01 | Buy |
4'-HYDROXYCHALCONE Chemical Properties,Uses,Production
Description
4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC50 = 47.3 μM) in vitro in a reversible and non-competitive manner.
Chemical Properties
yellow-cream powder
Uses
4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).
Uses
antineoplastic,
Definition
ChEBI: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 4'.
in vivo
4'-Hydroxychalcone has hepatoprotective activity against Acetaminophen induced hepatotoxicity in mice[2].
| Animal Model: | Male albino mice(5-30 g)[2] |
| Dosage: | 25 mg/kg, 50 mg/kg, 100 mg/kg |
| Administration: | Oral administration, 12h intervals, 4 doses |
| Result: | Significantly reduced the mortality rate induced by Acetaminophen (1 g/kg). |
4'-HYDROXYCHALCONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8831 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
View Lastest Price from 4'-HYDROXYCHALCONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 4'-HYDROXYCHALCONE
2657-25-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2024-11-19 | 4'-Hydroxychalcone
2657-25-2
|
US $107.00 / mg | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | 4'-HYDROXYCHALCONE
2657-25-2
|
US $1.00 / KG | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- 4'-HYDROXYCHALCONE
2657-25-2
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4'-Hydroxychalcone
2657-25-2
- US $107.00 / mg
- 99.86%
- TargetMol Chemicals Inc.
-
- 4'-HYDROXYCHALCONE
2657-25-2
- US $1.00 / KG
- 95%
- Career Henan Chemical Co