Ophthazin
- CAS No.
- 484-23-1
- Chemical Name:
- Ophthazin
- Synonyms
- c7441;C8H1ON6;nepresol;Ophthazin;tonolysin;nepressol;hypopresol;nepresolin;NSC 526654;cassella532
- CBNumber:
- CB1365502
- Molecular Formula:
- C8H10N6
- Molecular Weight:
- 190.21
- MDL Number:
- MFCD01250766
- MOL File:
- 484-23-1.mol
- MSDS File:
- SDS
| Melting point | 180°C (rough estimate) |
|---|---|
| Boiling point | 315.71°C (rough estimate) |
| Density | 1.3243 (rough estimate) |
| refractive index | 1.8100 (estimate) |
| pka | 3?+-.0.20(Predicted) |
| color | Orange crystals from H2O |
| FDA UNII | PCU411F5L6 |
| ATC code | C02DB01 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 2933998090 |
| Toxicity | LD50 i.p. in rats: 1084 mmol/kg (Steiner) |
Ophthazin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I779505 | 1,4-Dihydraziny-phthalazine | 484-23-1 | 100mg | $130 | 2021-12-16 | Buy |
| TRC | I779505 | 1,4-Dihydraziny-phthalazine | 484-23-1 | 10mg | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0303601 | 1,4-DIHYDRAZINO-PHTHALAZINE 95.00% | 484-23-1 | 5MG | $495.32 | 2021-12-16 | Buy |
| Matrix Scientific | 115247 | 1,4-Dihydrazinyl-phthalazine >95% | 484-23-1 | 500mg | $132 | 2021-12-16 | Buy |
| Matrix Scientific | 115247 | 1,4-Dihydrazinyl-phthalazine >95% | 484-23-1 | 1g | $203 | 2021-12-16 | Buy |
Ophthazin Chemical Properties,Uses,Production
Originator
Nepresol,Novartis
Uses
Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.
Definition
ChEBI: Dihydralazine is a member of phthalazines.
Manufacturing Process
115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.
Therapeutic Function
Antihypertensive
Safety Profile
Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.
Ophthazin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9639 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42958 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9648 | 58 |
| Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd. | 027-59420981,18702770802 | China | 1975 | 50 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |