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Ophthazin

CAS No.
484-23-1
Chemical Name:
Ophthazin
Synonyms
c7441;C8H1ON6;nepresol;Ophthazin;tonolysin;nepressol;hypopresol;nepresolin;NSC 526654;cassella532
CBNumber:
CB1365502
Molecular Formula:
C8H10N6
Molecular Weight:
190.21
MDL Number:
MFCD01250766
MOL File:
484-23-1.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:39

Ophthazin Properties

Melting point 180°C (rough estimate)
Boiling point 315.71°C (rough estimate)
Density 1.3243 (rough estimate)
refractive index 1.8100 (estimate)
pka 3?+-.0.20(Predicted)
color Orange crystals from H2O
FDA UNII PCU411F5L6
ATC code C02DB01

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P305+P351+P338-P310
HS Code  2933998090
Toxicity LD50 i.p. in rats: 1084 mmol/kg (Steiner)

Ophthazin price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC I779505 1,4-Dihydraziny-phthalazine 484-23-1 100mg $130 2021-12-16 Buy
TRC I779505 1,4-Dihydraziny-phthalazine 484-23-1 10mg $45 2021-12-16 Buy
American Custom Chemicals Corporation CHM0303601 1,4-DIHYDRAZINO-PHTHALAZINE 95.00% 484-23-1 5MG $495.32 2021-12-16 Buy
Matrix Scientific 115247 1,4-Dihydrazinyl-phthalazine >95% 484-23-1 500mg $132 2021-12-16 Buy
Matrix Scientific 115247 1,4-Dihydrazinyl-phthalazine >95% 484-23-1 1g $203 2021-12-16 Buy
Product number Packaging Price Buy
I779505 100mg $130 Buy
I779505 10mg $45 Buy
CHM0303601 5MG $495.32 Buy
115247 500mg $132 Buy
115247 1g $203 Buy

Ophthazin Chemical Properties,Uses,Production

Originator

Nepresol,Novartis

Uses

Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Definition

ChEBI: Dihydralazine is a member of phthalazines.

Manufacturing Process

115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.

Therapeutic Function

Antihypertensive

Safety Profile

Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.

Ophthazin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 51)Suppliers
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CONIER CHEM AND PHARMA LIMITED
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Shaanxi Dideu Medichem Co. Ltd
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Finetech Industry Limited
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Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15402 60
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9649 58
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd. 027-59420981,18702770802 China 1975 50
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8014 62
LABOTEST-BB LT00439820 DIHYDRALAZINE Ophthazin 1,4-dihydrazinonaphthalazine 1,4-dihydrazino-phthalazin 1,4-dihydrazinophthalazine 2,3-dihydro-1,4-phthalazinedionedihydrazone 4-phthalazinedione,2,3-dihydro-dihydrazone c7441 cassella532 tonolysin dihydralazin dihydrallazin dihydrazinophthalazine hypopresol nepresol nepresolin nepressol (4-hydrazinophthalazin-1-yl)hydrazine (4-hydrazinylphthalazin-1-yl)hydrazine 1,4-dihydrazinyl-Phthalazine NSC 526654 C8H1ON6 1,4-Dihydraziny-phthalazine (1Z)-4-hydrazinyl-1-hydrazinylidene-1,2-dihydrophthalazine Phthalazine, 1,4-dihydrazinyl- Ophthazin USP/EP/BP 4-Hydrazinyl-1-hydrazinylidene-1,2- dihydrophthalazine 1,4-bis(hydrazino)phthalazine 1,4-dihydrazono-1,2,3,4-tetrahydrophthalazine 484-23-1 C8H10N6H2SO425H2O Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals