Muscone
- CAS No.
- 541-91-3
- Chemical Name:
- Muscone
- Synonyms
- Musk;Muskone;(R)-(-)-Muscone;3-METHYL-1-CYCLOPENTADECANONE;MUSCONE;FEMA 3434;MGC126323;MGC126324;DL-MUSCONE;MUSCONE II
- CBNumber:
- CB1378768
- Molecular Formula:
- C16H30O
- Molecular Weight:
- 238.41
- MDL Number:
- MFCD00211114
- MOL File:
- 541-91-3.mol
- MSDS File:
- SDS
| Melting point | -15°C(lit.) |
|---|---|
| Boiling point | 95°C/0.1mmHg(lit.) |
| Density | 0.9221 |
| vapor pressure | 0.041Pa at 25℃ |
| FEMA | 3434 | 3-METHYL-1-CYCLOPENTADECANONE |
| refractive index | 1.4770 to 1.4810 |
| RTECS | GY0950000 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol (Sparingly) |
| form | Colorless oil. |
| color | Colourless |
| Odor | at 10.00 % in dipropylene glycol. sweet musk animal powdery fatty natural |
| Odor Type | musk |
| Water Solubility | 430μg/L at 20℃ |
| λmax | 285nm(EtOH)(lit.) |
| Merck | 14,6313 |
| JECFA Number | 1402 |
| LogP | 6.06 at 25℃ |
| Substances Added to Food (formerly EAFUS) | 3-METHYL-1-CYCLOPENTADECANONE |
| CAS DataBase Reference | 541-91-3(CAS DataBase Reference) |
| EWG's Food Scores | 2 |
| FDA UNII | 5JO79R7S9R |
| NIST Chemistry Reference | Cyclopentadecanone, 3-methyl-(541-91-3) |
| EPA Substance Registry System | Cyclopentadecanone, 3-methyl- (541-91-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2914.29.5000 | |||||||||
| NFPA 704 |
|
Muscone price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M0198 | MUSK (519-end), active, GST tagged human PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 541-91-3 | 10μG | $524 | 2024-03-01 | Buy |
| TCI Chemical | M2611 | Muscone >97.0%(GC) | 541-91-3 | 200mg | $149 | 2024-03-01 | Buy |
| TCI Chemical | M2611 | Muscone >97.0%(GC) | 541-91-3 | 1g | $514 | 2024-03-01 | Buy |
| Alfa Aesar | J67481 | Muscone, 99% | 541-91-3 | 500mg | $365 | 2021-12-16 | Buy |
| Alfa Aesar | J67481 | Muscone, 99% | 541-91-3 | 100mg | $115 | 2021-12-16 | Buy |
Muscone Chemical Properties,Uses,Production
Chemical Properties
3-Methyl-1-cyclopentadecanone has a soft, sweet, tenacious, musky odor.
Chemical Properties
Musk is secreted exclusively by the male animals of Moschus moschiferus, a wild deer living in themountains of Nepal,Tibet, and Mongolia.Thelight yellow secretion with a salve consistency accumulates in the abdominal pouch and probably serves to attract the females. When the pouch is dried, the secretion solidifies to form a brittle, brown mass with a characteristic odor. Since several Moschus species occur, large variations exist in the quality and specifications of musk. Hunting of the animals has been prohibited; therefore, only small quantities ofmusk are occasionally offered at extremely high prices. In the United States and Europe, naturalmusk is no longer used as a fragrance ingredient.
Chemical Properties
Colorless oily liquid
Chemical Properties
Muscone is an odoriferous constituent of natural musk. It is a colorless liquid with very soft, sweet, musky odor and a perfumery, animal tonality.Numerous syntheses have been developed for its preparation including enantioselective methods to obtain the naturally occurring (3R)-enantiomer (l-muscone,. Because of its excellent stability, it can be used in awide range of products to give elegant,warm, animal notes. It is important for the reconstitution of naturalmusk.
Occurrence
Reported found in natural musk
Uses
Muscone protects PC12 cells against glutamate-induced apoptosis.
Preparation
From condensation of dodecamethyl-ene-α,ω-dimethylketone hexadecane.
Aroma threshold values
Detection: 9.8 ppb
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 1906, 1980 DOI: 10.1021/jo01298a029
Tetrahedron Letters, 17, p. 2617, 1976
Flammability and Explosibility
Not classified
Biological Activity
muscone is a potent anti-inflammatory agent, which has been implicated in reducing proinflammatory cytokines and end-plate degeneration [1]. muscone is a territorial releaser pheromone in moschus moschiferus. muscone is not produced by humans. muscone is animal pheromone with no effects on humans comparable to those of androstadienone [2]. (±)-muscone is an odoriferous constituent of musk, a glandular secretion originally collected from the male musk deer [3].
Safety Profile
Low oral and skin contact toxicity. A skin irritant. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes.
in vitro
muscone reversed il-1β-induced upregulation of il-1β, tumor necrosis factor α, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of col2α1 and aggrecan. in end-plate cartilage cultures, pretreatment with muscone (6.25, 12.5, 25 μmol/l) inhibited the il-1β-induced phosphorylation of extracellular signal-regulated kinases 1/2 and c-jun n-terminal kinase in a dose-dependent manner [1].
in vivo
in a rat model with induced intervertebral disc degeneration, muscone inhibited the expression of prostaglandin e2, 6-keto-prostaglandin f1α, il-1β, and tumor necrosis factor α and recovered the structural distortion of the degenerative disc [1].
References
[1] liang q q, zhang m, zhou q, et al. muscone protects vertebral end-plate degeneration by antiinflammatory property[j]. clinical orthopaedics and related research, 2010, 468(6): 1600-1610.
[2] jacob s, garcia s, hayreh d, et al. psychological effects of musky compounds: comparison of androstadienone with androstenol and muscone[j]. hormones and behavior, 2002, 42(3): 274-283.
[3] fujimoto, s. ,yoshikawa, k.,itoh, m., et al. synthesis of (r)- and (s)- muscone. bioscience, biotechnology, and biochemistry 66(6), 1389-1392 (2002).
Muscone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 | sales@qinmuchem.com | China | 1009 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8811 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18153 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9214 | 55 |
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View Lastest Price from Muscone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-25 | Muscone
541-91-3
|
US $120.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-11-19 | Muscone
541-91-3
|
US $39.00-97.00 / mg | 99.28% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-07 | Muscone
541-91-3
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd |