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ChemicalBook >> CAS DataBase List >>2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Structure
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 structure
CAS No.
729589-58-6
Chemical Name:
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
Synonyms
2fLI;2-Fly;f-LIGRLO-NH2;2-f-LIGRLO-NH2;2F-LIGRLO-AMIDE;PAR-2 AGONIST II;2-Furoyl-LIGRLO-NH2;2-Furoyl-LIGRLO-amid;2-FUROYL-LIGRLO-AMIDE;2-(2-FUROYL)-LIGRLOAMIDE
CBNumber:
CB1382037
Molecular Formula:
C36H63N11O8
Molecular Weight:
777.95
MDL Number:
MFCD08460329
MOL File:
729589-58-6.mol
Last updated:2023-06-30 15:45:59
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2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Properties

Density 1.33±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in H2O
form powder
pka 12.91±0.46(Predicted)
color white
Water Solubility Soluble to 1 mg/ml in water

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F3681 2-Furoyl-LIGRLO-amide trifluoroacetate salt ≥97% (HPLC) 729589-58-6 1mg $171 2024-03-01 Buy
Alfa Aesar J66850 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 729589-58-6 1mg $70.5 2021-12-16 Buy
Alfa Aesar J66850 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 729589-58-6 5mg $258 2021-12-16 Buy
Cayman Chemical 14594 2-furoyl-LIGRLO amide ≥95% 729589-58-6 1mg $116 2024-03-01 Buy
Tocris 3015 2-Furoyl-LIGRLO-amide 729589-58-6 1 $132 2021-12-16 Buy
Product number Packaging Price Buy
F3681 1mg $171 Buy
J66850 1mg $70.5 Buy
J66850 5mg $258 Buy
14594 1mg $116 Buy
3015 1 $132 Buy

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Chemical Properties,Uses,Production

Uses

2-Furoyl-LIGRLO-amide trifluoroacetate salt may be used as a protease-activated receptor 2 (PAR2) agonist in endothelial progenitor cells (EPCs) and in transient receptor potential cation channel subfamily V member (TRPV4)-transfected HEK293t cells.

General Description

2-Furoyl-LIGRLO-amide trifluoroacetate salt is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.

Biological Activity

potent and selective par2 receptor agonist (pd2 = 7.0). causes a dose-dependent relaxation of murine femoral arteries.

Biochem/physiol Actions

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist. PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation. 2-Furoyl-LIGRLO-amide is nearly 100-fold more potent than SLIGRL-NH2 (Cat. No. S9317). 2-Furoyl-LIGRLO-amide caused both an endothelium-dependent relaxation and an endothelium-independent contraction. It produced delayed (6 hours later) facilitation of capsaicin-evoked visceral nociception, an effect being much more potent than SLIGRL-NH2. Such effects were mimicked by i.col. trypsin. 2-f-LIGRL-NH2, coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-f-LIGRL-NH2 moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. It induced a similar dose-dependent increase in Ca2 levels in the presence and absence of b-arrestins.

storage

Store at -20°C

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Suppliers

Global( 72)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Alfa Chemistry 		Info@alfa-chemistry.com United States 24072 58
Chengdu Youngshe Chemical Co., Ltd. 		+8618108235634 Cecilia@youngshechem.com China 2345 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3512 58
Nanjing TGpeptide 		+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Zhejiang Hangyu API Co., Ltd 		+8617531972939 anna@api-made.com China 2943 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33338 58
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 		58
career henan chemical co 		58
BOC Sciences 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Alfa Chemistry 		58
Chengdu Youngshe Chemical Co., Ltd. 		58
Hebei Miaoyin Technology Co.,Ltd 		58
Nanjing TGpeptide 		58
Zhejiang Hangyu API Co., Ltd 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58

View Lastest Price from 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Furoyl-LIGRLO-amide trifluoroacetate salt pictures 2020-02-19 2-Furoyl-LIGRLO-amide trifluoroacetate salt
729589-58-6
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 pictures 2020-02-19 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
729589-58-6
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co

729589-58-6(2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2)Related Search:

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
PAR-2 AGONIST II PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-(2-FUROYL)-LIGRLOAMIDE 2-(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE (MOUSE, RAT) 2F-LIGRLO-AMIDE 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-FUROYL-LIGRLO-AMIDE (2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat) 2fLI 2-f-LIGRLO-NH2 2-Fly 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt 2-Furoyl-LIGRLO-amide trifluoroacetate salt f-LIGRLO-NH2 2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist L-Ornithinamide, N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl- N-(2-Furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide 2-Furoyl-LIGRLO-amid 2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor2 (PAR2) Agonist {Fur-2-oyl}-LIGRL-{Orn}-NH2 2-Furoyl-LIGRLO-amide (2Fly), PAR2 agonist 729589-58-6 C36H63N11O8