ChemicalBook >> CAS DataBase List >>AB-423
AB-423
- CAS No.
- 1572510-80-5
- Chemical Name:
- AB-423
- Synonyms
- AB-423;CS-2686;AB423;AB-423;AB 423;AB-423, 10 mM in DMSO;AB 423,HBV,AB423,inhibit,Hepatitis B virus,AB-423,Inhibitor;N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide;Benzamide, N-(3,4-difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]-
- CBNumber:
- CB13960102
- Molecular Formula:
- C17H17F3N2O3S
- Molecular Weight:
- 386.39
- MDL Number:
- MFCD31657418
- MOL File:
- 1572510-80-5.mol
Last updated:2025-04-17 18:22:24
| Density | 1.372±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility |
DMSO:88.5(Max Conc. mg/mL);229.04(Max Conc. mM) Ethanol:77.0(Max Conc. mg/mL);199.28(Max Conc. mM) |
| form | Solid |
| pka | 10.84±0.70(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 1572510-80-5 |
AB-423 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D447900 | N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide | 1572510-80-5 | 5mg | $495 | 2021-12-16 | Buy |
| TRC | D447900 | N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide | 1572510-80-5 | 1mg | $165 | 2021-12-16 | Buy |
| ChemScene | CS-0043473 | AB-423 99.60% | 1572510-80-5 | 5mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-0043473 | AB-423 99.60% | 1572510-80-5 | 10mg | $330 | 2021-12-16 | Buy |
| ChemScene | CS-0043473 | AB-423 99.60% | 1572510-80-5 | 25mg | $660 | 2021-12-16 | Buy |
AB-423 Chemical Properties,Uses,Production
Uses
N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide, is an inhibitor of HBV capsid assembly. AB-423 shows inhibitory effect on rcDNA production in AML12-HBV10 and HepDE19 cells with EC50s of ～0.260 μM
in vivo
AB-423 (30 and 100 mg/kg, p.o. bid) blocks HBV replication in a mouse model of HBV. AB-423 (100 mg/kg, p.o. bid) with entecavir (ETV, 100 ng/mg, qd, p.o.) or 0.1 mg/kg dose of ARB-1467 potently inhibits serum HBV DNA in an HDI model of HBV in immunodeficient NOD-SCID mice[1].
AB-423 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 57)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
AB-423
CS-2686
AB423;AB-423;AB 423
Benzamide, N-(3,4-difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]-
N-(3,4-Difluorophenyl)-2-fluoro-5-[[[(1R)-1-methylpropyl]amino]sulfonyl]benzamide
AB 423,HBV,AB423,inhibit,Hepatitis B virus,AB-423,Inhibitor
AB-423, 10 mM in DMSO
1572510-80-5