1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
- CAS No.
- 55314-16-4
- Chemical Name:
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
- Synonyms
- 4G-951;Imatinib Impurity 19;Imatinib Impurity 74;Imatinib EP Impurity A;Imatinib USP Impurity A;Nilotinib??Intermediates?B;Imatinib Related Compound A;Imatinib Dimethylamino Impurity;3-Dimethylamino-1-pyridin-3-yl-pr;3-[3-(Dimethylamino)acryloyl]pyridine
- CBNumber:
- CB1406106
- Molecular Formula:
- C10H12N2O
- Molecular Weight:
- 176.22
- MDL Number:
- MFCD00115180
- MOL File:
- 55314-16-4.mol
Melting point | 86-88 |
---|---|
Boiling point | 281.4±36.0 °C(Predicted) |
Density | 1.070±0.06 g/cm3(Predicted) |
vapor pressure | 0.049Pa at 20℃ |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Soluble in chloroform and dichloromethane. |
form | powder to crystal |
pka | 6.19±0.70(Predicted) |
color | Light yellow to Brown |
InChIKey | MZLRFUCMBQWLNV-FNORWQNLSA-N |
LogP | 0.26 at 20℃ and pH7.2 |
Surface tension | 71.8mN/m at 1.008g/L and 20℃ |
CAS DataBase Reference | 55314-16-4(CAS DataBase Reference) |
FDA UNII | MD6L0C82BN |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 26-36/37/39 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29333990 | |||||||||
NFPA 704 |
|
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one price More Price(44)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | D3949 | 2-(Dimethylamino)vinyl 3-Pyridyl Ketone >98.0%(GC) | 55314-16-4 | 1g | $68 | 2023-06-20 | Buy |
TCI Chemical | D3949 | 2-(Dimethylamino)vinyl 3-Pyridyl Ketone >98.0%(GC) | 55314-16-4 | 5g | $204 | 2023-06-20 | Buy |
Alfa Aesar | H54187 | 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97% | 55314-16-4 | 5g | $208 | 2021-12-16 | Buy |
Alfa Aesar | H54187 | 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97% | 55314-16-4 | 1g | $53.2 | 2021-12-16 | Buy |
Alfa Aesar | H54187 | 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97% | 55314-16-4 | 250mg | $17.8 | 2021-12-16 | Buy |
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Chemical Properties,Uses,Production
Description
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.
Chemical Properties
Off-White Solid
Uses
3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.
Uses
Rasagiline intermediate
Solubility in organics
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 | jennysun@yzqyyykj.com | China | 71 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9284 | 55 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2966 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
View Lastest Price from 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-10-18 | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
55314-16-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2022-06-21 | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
55314-16-4
|
US $0.00 / g | 10g | 98% | 10tons | Yangzhou Qinyuan Pharmatech Co.,ltd | ||
2021-10-26 | 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
55314-16-4
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
55314-16-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
55314-16-4
- US $0.00 / g
- 98%
- Yangzhou Qinyuan Pharmatech Co.,ltd
- 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
55314-16-4
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
55314-16-4(1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one)Related Search:
1of4