11-KETO-BETA-BOSWELLIC ACID
- CAS No.
- 17019-92-0
- Chemical Name:
- 11-KETO-BETA-BOSWELLIC ACID
- Synonyms
- Pharoxifene;Raloxifenum;11-Oxo-β-boswellic Acid;11-Oxo-β-boswellic acid;β-Boswellic acid,11-keto;11-keto-β-Boswellic Acid;β-Boswellic acid,11-keto;Boswellic Acid Impurity 2;11-KETO-BETA-BOSWELLIC ACID;Beta-boswellic acid,11-keto
- CBNumber:
- CB1415526
- Molecular Formula:
- C30H46O4
- Molecular Weight:
- 470.68
- MDL Number:
- MFCD06656312
- MOL File:
- 17019-92-0.mol
- MSDS File:
- SDS
| Melting point | 190～192℃ |
|---|---|
| Boiling point | 591.8±50.0 °C(Predicted) |
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | ≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide |
| pka | 4.46±0.70(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | insoluble in water |
| InChIKey | YIMHGPSYDOGBPI-IQQSWPBXSA-N |
| LogP | 7.100 (est) |
| FDA UNII | 0S3BIF6H0Q |
11-KETO-BETA-BOSWELLIC ACID price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89169 | 11-Keto-β-boswellic acid phyproof? Reference Substance | 17019-92-0 | 10MG | $584 | 2024-03-01 | Buy |
| Sigma-Aldrich | 78535 | 11-Keto-β-boswellic acid analytical standard | 17019-92-0 | 5mg | $561 | 2024-03-01 | Buy |
| Cayman Chemical | 11668 | 11-keto-β-Boswellic Acid ≥95% | 17019-92-0 | 1mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 11668 | 11-keto-β-Boswellic Acid ≥95% | 17019-92-0 | 5mg | $412 | 2024-03-01 | Buy |
| Cayman Chemical | 11668 | 11-keto-β-Boswellic Acid ≥95% | 17019-92-0 | 10mg | $684 | 2024-03-01 | Buy |
11-KETO-BETA-BOSWELLIC ACID Chemical Properties,Uses,Production
Uses
A constitutent of frankincense (olibanum) with anti-inflammatory properties. It has been shown to trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.
Biological Activity
37.9 μm: blocks a2780 (cis-platin resistant ovarian cancer cells) [1].11-keto-β-boswellic acid, known as kba, is a naturally occurring pentacyclic triterpene isolated from the gum resin of the tree boswellia serrata. kba is non-redox, specific leukotriene synthesis inhibitors through the inhibition of 5-lipoxygenase (5-lox) which has anti-arthritic and anti-inflammatory activities. 5-lox catalyzes essential fatty acids substrates into leukotrienes and a variety of other biologically active products. kba is a novel activator of nuclear factor erythroid-2-related factor 2 (nrf2), which protects against cerebral ischemic injury.
in vitro
kba, concentration dependently, decreased the formation of leukotriene b4 and the synthesis of all 5-lox products from endogenous arachidonic acid in rat peritoneal neutrophils. in contrast, kba exerted no remarkable effects on the 12-lipoxygenase and cyclooxygenase activities. [2].
in vivo
adult male sprague–dawley rats were injected kab intraperitoneally at a dose of 25 mg/kg for 48 hours. kab remarkably decreased infarct volumes as well as apoptotic cells at 1 h, and then increased neurologic scores when applied 48 h. moreover, posttreatment with kba induced the decrease of malondialdehyde levels and the increase of protein nrf2 and heme oxygenase-1 expression in brain tissues, indicating that the nrf2/ho-1 pathway was involved in the neuroprotection of kba against oxidative stress-induced ischemic injury [3].
IC 50
35.8 μm: inhibits mcf-7 (human breast adenocarcinoma) [1].
References
[1]. csuk, r., barthel-niesen, a., barthel, a., schffer, r., & al-harrasi, a. 11-keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells. european journal of medicinal chemistry. 2015; 100: 98-105.
[2]. safayhi, h., mack, t. h. o. m. a. s., sabieraj, j. o. a. c. h. i. m., anazodo, m. i., subramanian, l. r., & ammon, h. p. boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. journal of pharmacology and experimental therapeutics. 1992; 261(3):1143-1146.
[3]. ding, y., chen, m., wang, m., li, y., & wen, a. posttreatment with 11-keto-β-boswellic acid ameliorates cerebral ischemia–reperfusion injury: nrf2/ho-1 pathway as a potential mechanism. molecular neurobiology. 2014; 52(3): 1430-1439.
11-KETO-BETA-BOSWELLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
View Lastest Price from 11-KETO-BETA-BOSWELLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 11-?Keto-?beta-?boswellic acid
17019-92-0
|
US $55.00-222.00 / mg | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-02 | 11-Keto-beta-boswellic acid
17019-92-0
|
US $1400.00 / mg | 1mg | 98 | 500 Kg | R&D Scientific Inc. | |
 |
2023-02-13 | 11-Keto β-Boswellic Acid
17019-92-0
|
US $90.00 / KG | 1KG | 99% | 100mt | Hebei baicao biology science and technology co., ltd |
-
- 11-?Keto-?beta-?boswellic acid
17019-92-0
- US $55.00-222.00 / mg
- 99.68%
- TargetMol Chemicals Inc.
-
- 11-Keto-beta-boswellic acid
17019-92-0
- US $1400.00 / mg
- 98
- R&D Scientific Inc.
-
- 11-Keto β-Boswellic Acid
17019-92-0
- US $90.00 / KG
- 99%
- Hebei baicao biology science and technology co., ltd