O-1918
- CAS No.
- 536697-79-7
- Chemical Name:
- O-1918
- Synonyms
- O-1918;1,3-DIMETHOXY-5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-BENZENE;Benzene, 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-
- CBNumber:
- CB1422902
- Molecular Formula:
- C19H26O2
- Molecular Weight:
- 286.41
- MDL Number:
- MFCD08062137
- MOL File:
- 536697-79-7.mol
| Boiling point | 383.9±42.0 °C(Predicted) |
|---|---|
| Density | 0.981±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| color | Colorless to light yellow |
| FDA UNII | 2DGR9Z5BT3 |
O-1918 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10004914 | O-1918 ≥95% | 536697-79-7 | 1mg | $30 | 2024-03-01 | Buy |
| Cayman Chemical | 10004914 | O-1918 ≥95% | 536697-79-7 | 5mg | $113 | 2024-03-01 | Buy |
| Cayman Chemical | 10004914 | O-1918 ≥95% | 536697-79-7 | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 10004914 | O-1918 ≥95% | 536697-79-7 | 25mg | $315 | 2024-03-01 | Buy |
| Tocris | 2288 | O-1918 ≥97%(HPLC) | 536697-79-7 | 10 | $216 | 2021-12-16 | Buy |
O-1918 Chemical Properties,Uses,Production
Uses
O-1918 is a cannabidiol analog and a selective antagonist at the endothelial cannabidiol receptor. It is an inhibitor of GPR18. O-1918 can also induce endothelium-dependent vasodilation.
Biological Activity
Selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB 1 or CB 2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol).
Enzyme inhibitor
This endocannabinoid antagonist (FW = 286.42 g/mol; CAS 536697-79-7), systematically named 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1- methylethenyl)-2-cyclohexen-1-yl]benzene, is a cannabidinodiol analogue that selectively targets a putative G-coupled endothelial anandamide receptor that is distinct from CB1 or CB2 endocannabinoid receptors. O- 1918 does not bind to CB1 or CB2 receptors and does not cause vasorelaxation at concentrations up to 30 μM, but inhibits the vasorelaxant effects of abn-cbd and anandamide in a concentration-dependent manner (1- 30 μM). (See abn-cbd; Anandamide; Oleamide). While the atypical cannabinoids O-1602 and abn-cbd (or abnormal cannabidiol) stimulate GPR55-dependent GTPgS activity (EC50 ~ 2 nM), O-1918 antagonizes such effects. O-1918 is involved in the delayed hypotension induced by anandamide in anaesthetized rats.
storage
Store at -20°C
O-1918 Preparation Products And Raw materials
Raw materials
Preparation Products
O-1918 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32079 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 13774214275 | gaojun@univ-bio.com | China | 24990 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29794 | 58 |
| Hubei Aiputi Bioengineering Co., Ltd. | 17762444226 | d17762444226@163.com | China | 2402 | 58 |