Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide

N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide

N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Structure
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide structure
CAS No.
684234-55-7
Chemical Name:
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide
Synonyms
WAY-323091;PARP-1-IN-2;N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide;2(1H)-Phthalazineacetamide, N-(3-chlorophenyl)-4-(4-chlorophenyl)-1-oxo-;N-(3-Chlorophenyl)-2-(4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl)acetamide , PARP-1-IN-2
CBNumber:
CB14308671
Molecular Formula:
C22H15Cl2N3O2
Molecular Weight:
424.28
MDL Number:
MOL File:
684234-55-7.mol
Last updated:2024-07-02 08:55:00
Request For Quotation

N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Properties

storage temp. 4°C, protect from light
solubility DMSO : 83.33 mg/mL (196.40 mM; Need ultrasonic)
form Solid
color White to off-white

N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Chemical Properties,Uses,Production

Biological Activity

PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1]. PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells[1].PARP-1-IN-2 (0-10 μM, 24 h) decreases the expression of pro-caspase-3 and phosphorylated AKT, increases the expression of caspase-3, caspase-9 protein and the cleaved PARP-1[1].

References

[1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.

N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9941 58
Jingmo (Xiamen) Biotechnology Co., Ltd 13621943973 sales@jamxmpharmatech.com China 1105 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 2860 58
Zhengzhou convergence chemical co., LTD 0371-0371-55153829 18003835034 2853979819@qq.com China 9459 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 63720 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5585 58
Guangdong Shengke Biochemical Technology Co., Ltd. 189-25112307 18925113981 3809205144@qq.com China 10000 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 market@aladdin-e.com China 48465 58
Supplier Advantage
Aladdin Scientific 		58
Shanghai Chaolan Chemical Technology Center 58
Jingmo (Xiamen) Biotechnology Co., Ltd 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Zhengzhou convergence chemical co., LTD 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Guangdong Shengke Biochemical Technology Co., Ltd. 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide 2(1H)-Phthalazineacetamide, N-(3-chlorophenyl)-4-(4-chlorophenyl)-1-oxo- PARP-1-IN-2 WAY-323091 N-(3-Chlorophenyl)-2-(4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl)acetamide , PARP-1-IN-2 684234-55-7