N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide
- CAS No.
- 684234-55-7
- Chemical Name:
- N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide
- Synonyms
- WAY-323091;PARP-1-IN-2;N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide;2(1H)-Phthalazineacetamide, N-(3-chlorophenyl)-4-(4-chlorophenyl)-1-oxo-;N-(3-Chlorophenyl)-2-(4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl)acetamide , PARP-1-IN-2
- CBNumber:
- CB14308671
- Molecular Formula:
- C22H15Cl2N3O2
- Molecular Weight:
- 424.28
- MDL Number:
- MOL File:
- 684234-55-7.mol
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Chemical Properties,Uses,Production
Biological Activity
PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1]. PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells[1].PARP-1-IN-2 (0-10 μM, 24 h) decreases the expression of pro-caspase-3 and phosphorylated AKT, increases the expression of caspase-3, caspase-9 protein and the cleaved PARP-1[1].
References
[1]. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3-chlorophenyl)-2-[4-(4-chlorophenyl)-1-oxophthalazin-2-yl]acetamide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9941 | 58 |
Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973 | sales@jamxmpharmatech.com | China | 1105 | 58 |
Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 2860 | 58 |
Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 | 2853979819@qq.com | China | 9459 | 58 |
Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 63720 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5585 | 58 |
Guangdong Shengke Biochemical Technology Co., Ltd. | 189-25112307 18925113981 | 3809205144@qq.com | China | 10000 | 58 |
Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48465 | 58 |