ChemicalBook >> CAS DataBase List >>JH-VIII-157-02
JH-VIII-157-02
- CAS No.
- 1639422-97-1
- Chemical Name:
- JH-VIII-157-02
- Synonyms
- JH-VIII-157-02;1H-Pyrazole-1-acetamide, 4-(3-cyano-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethyl-;CD246,Cluster of differentiation 246,inhibit,Anaplastic lymphoma kinase,Anaplastic lymphoma kinase (ALK),ALK tyrosine kinase receptor,Inhibitor,JHVIII15702,JH VIII 157 02
- CBNumber:
- CB14668070
- Molecular Formula:
- C28H27N5O2
- Molecular Weight:
- 465.55
- MDL Number:
- MFCD31657417
- MOL File:
- 1639422-97-1.mol
Last updated:2024-07-02 08:55:01
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
JH-VIII-157-02 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0043469 | JH-VIII-157-02 98.86% | 1639422-97-1 | 5mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0043469 | JH-VIII-157-02 98.86% | 1639422-97-1 | 10mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0043469 | JH-VIII-157-02 98.86% | 1639422-97-1 | 25mg | $1600 | 2021-12-16 | Buy |
| ChemScene | CS-0043469 | JH-VIII-157-02 98.86% | 1639422-97-1 | 50mg | $2600 | 2021-12-16 | Buy |
| ChemScene | CS-0043469 | JH-VIII-157-02 98.86% | 1639422-97-1 | 100mg | $4500 | 2021-12-16 | Buy |
JH-VIII-157-02 Chemical Properties,Uses,Production
Biological Activity
JH-VIII-157-02, a structural analog of alectinib, is an ALK inhibitor with IC50 of 2 nM for echinoderms microtubule-associated protein-like 4 (EML4)-ALK G1202R.
in vivo
JH-VIII-157-02 exhibits good oral bioavailability following an oral dose of 10 mg/kg in mice. JH-VIII-157-02 also penetrates the CNS of mice.
target
IC50: 2 nM (EML4-ALK G1202R, cell assay), 2 nM (EML4-ALK wt , cell assay), 2 nM (EML4-ALK C1156Y, cell assay) , 2 nM (EML4-ALK F1174L, cell assay), 2 nM (EML4-ALK F1174L, cell assay)
JH-VIII-157-02 Preparation Products And Raw materials
Raw materials
Preparation Products
JH-VIII-157-02 Suppliers
Global( 22)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9874 | 58 |
| Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. | 021-58521787 17701827760 | starpharmsh@gmail.com | China | 208 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shenyang Maud Pharmaceutical Technology Co., Ltd. | 024-23982345 | 1020788318@qq.com | China | 2254 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
JH-VIII-157-02
1H-Pyrazole-1-acetamide, 4-(3-cyano-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethyl-
CD246,Cluster of differentiation 246,inhibit,Anaplastic lymphoma kinase,Anaplastic lymphoma kinase (ALK),ALK tyrosine kinase receptor,Inhibitor,JHVIII15702,JH VIII 157 02
1639422-97-1