| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:JH-VIII-157-02
CAS:1639422-97-1
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| | JH-VIII-157-02 Basic information |
| Product Name: | JH-VIII-157-02 | | Synonyms: | JH-VIII-157-02;1H-Pyrazole-1-acetamide, 4-(3-cyano-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol-8-yl)-N,N-dimethyl-;CD246,Cluster of differentiation 246,inhibit,Anaplastic lymphoma kinase,Anaplastic lymphoma kinase (ALK),ALK tyrosine kinase receptor,Inhibitor,JHVIII15702,JH VIII 157 02 | | CAS: | 1639422-97-1 | | MF: | C28H27N5O2 | | MW: | 465.55 | | EINECS: | | | Product Categories: | | | Mol File: | 1639422-97-1.mol |  |
| | JH-VIII-157-02 Chemical Properties |
| Boiling point | 751.9±60.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 25 mg/mL (53.70 mM) | | pka | 13.70±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | JH-VIII-157-02 Usage And Synthesis |
| Biological Activity | JH-VIII-157-02, a structural analog of alectinib, is an ALK inhibitor with IC50 of 2 nM for echinoderms microtubule-associated protein-like 4 (EML4)-ALK G1202R. | | in vivo | JH-VIII-157-02 exhibits good oral bioavailability following an oral dose of 10 mg/kg in mice. JH-VIII-157-02 also penetrates the CNS of mice. | | target | IC50: 2 nM (EML4-ALK G1202R, cell assay), 2 nM (EML4-ALK wt , cell assay), 2 nM (EML4-ALK C1156Y, cell assay) , 2 nM (EML4-ALK F1174L, cell assay), 2 nM (EML4-ALK F1174L, cell assay) |
| | JH-VIII-157-02 Preparation Products And Raw materials |
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