TRIFLUOPERAZINE DIMALEATE
- CAS No.
- 605-75-4
- Chemical Name:
- TRIFLUOPERAZINE DIMALEATE
- Synonyms
- Trifluoperazine maleate;TRIFLUOPERAZINE DIMALEATE;WTMXVVQBBRYSLL-SPIKMXEPSA-N;Trifluoperazine maleate (JAN);TRIFLUOPERAZINE DIMALEATE SALT;10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-phenothiazinmale
- CBNumber:
- CB1468456
- Molecular Formula:
- C29H34F3N3O8S
- Molecular Weight:
- 641.66
- MDL Number:
- MFCD00135195
- MOL File:
- 605-75-4.mol
| FDA UNII | AN9ZJ2YUI0 |
|---|
TRIFLUOPERAZINE DIMALEATE Chemical Properties,Uses,Production
Uses
Trifluoperazine dimaleate, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dimaleate is a potent α1-adrenergic receptor antagonist. Trifluoperazine dimaleate is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dimaleate is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dimaleate can be used for the research of schizophrenia. Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].
Safety Profile
Poison by intravenous route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of Fí, SOx, and NOx.
References
[1] Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70. PMID:6135146
[2] Santofimia-Casta?o P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28. DOI:10.1172/JCI127223
[3] Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545. DOI:10.1002/14651858.CD003545.pub2
[4] Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22. DOI:10.3928/02793695-20151223-01
[5] Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160. DOI:10.1016/0166-3542(91)90032-m
TRIFLUOPERAZINE DIMALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
TRIFLUOPERAZINE DIMALEATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| DAYANG CHEM (HANGZHOU) CO.,LTD | +8617705817739 | info@dycnchem.com | China | 53881 | 58 |
| 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 |
| Supplier | Advantage |
|---|---|
| DAYANG CHEM (HANGZHOU) CO.,LTD | 58 |
| 69 | |
| SPIRO PHARMA | 55 |