CEVIMELINE, HYDROCHLORIDE SALT
- CAS No.
- 107233-08-9
- Chemical Name:
- CEVIMELINE, HYDROCHLORIDE SALT
- Synonyms
- Evoxac;AF-102B;SNI-2011;3R)-rel-;Hsdb 7286;Cevimeline;3]oxathiolane];AF-102B;FKS-508;CevimelineHClSalt;CeviMeline(Evoxac)
- CBNumber:
- CB1490161
- Molecular Formula:
- C10H17NOS
- Molecular Weight:
- 199.31
- MDL Number:
- MFCD01961045
- MOL File:
- 107233-08-9.mol
| Melting point | 195-197°C |
|---|---|
| Boiling point | 308.5±42.0 °C(Predicted) |
| Density | 1.19 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 9.51±0.40(Predicted) |
| CAS DataBase Reference | 107233-08-9 |
| NCI Dictionary of Cancer Terms | Evoxac |
| FDA UNII | K9V0CDQ56E |
| NCI Drug Dictionary | Evoxac |
| ATC code | N07AX03 |
CEVIMELINE, HYDROCHLORIDE SALT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FC146883 | Cevimeline, hydrochloridesalt | 107233-08-9 | 1mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A3299 | Cevimeline | 107233-08-9 | 5mg | $156 | 2021-12-16 | Buy |
| AK Scientific | X7254 | Cevimeline | 107233-08-9 | 2mg | $190 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC146883 | Cevimeline, hydrochloridesalt | 107233-08-9 | 5mg | $207 | 2021-12-16 | Buy |
| ApexBio Technology | A3299 | Cevimeline | 107233-08-9 | 10mg | $229 | 2021-12-16 | Buy |
CEVIMELINE, HYDROCHLORIDE SALT Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A muscarinic M1 and M3 receptor agonist. Sialagogue
Biological Activity
cevimeline is a muscarinic receptor agonist especially on the m1 and m3 receptors. [1]cevimeline has been approved for use against symptoms of dry mouth by activating the m3 receptors of the parasympathetic nervous system. cevimeline is effective and safe in improving symptoms of dry eye with 20 mg three times per day [2]. cevimeline increased the intracellular ca+ level in parotid gland acinar cells over 1 μm and rat, enhanced the excitability via muscarinic receptors, thereby, cevimeline alleviates dry mouth symptoms by stimulating secretion by the salivary glands. cevimeline has a longer duration of salivation[3]. cevimeline plays a part in alzheimer’s disease. cevimeline decreased aβ (1–40) level in the cerebrospinal fluid (csf) at 1 mg/kg without changing α-apps in rabbit and significantly decreased csf aβ in ad patients.[4]
References
1. f. b. vivino, i. al-hashimi, z. khan, f. g. leveque, p. l. salisbury, 3rd, t. k. tran-johnson, c. c. muscoplat, m. trivedi, b. goldlust and s. c. gallagher, arch intern med 1999, 159, 174-181. 2. m. ono, e. takamura, k. shinozaki, t. tsumura, t. hamano, y. yagi and k. tsubota, am j ophthalmol 2004, 138, 6-17. 3. k. ono, t. inagaki, t. iida, r. hosokawa and k. inenaga, j med invest 2009, 56 suppl, 375. 4. a. fisher, z. pittel, r. haring, n. bar-ner, m. kliger-spatz, n. natan, i. egozi, h. sonego, i. marcovitch and r. brandeis, j mol neurosci 2003, 20, 349-356.
CEVIMELINE, HYDROCHLORIDE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12839 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
View Lastest Price from CEVIMELINE, HYDROCHLORIDE SALT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-31 | CEVIMELINE, HYDROCHLORIDE SALT
107233-08-9
|
US $9.90 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2023-08-29 | CEVIMELINE, HYDROCHLORIDE SALT
107233-08-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2019-07-06 | CEVIMELINE, HYDROCHLORIDE SALT
107233-08-9
|
US $15.00 / KG | 1KG | 98% | 1000kg | Career Henan Chemical Co |
-
- CEVIMELINE, HYDROCHLORIDE SALT
107233-08-9
- US $9.90 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- CEVIMELINE, HYDROCHLORIDE SALT
107233-08-9
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- CEVIMELINE, HYDROCHLORIDE SALT
107233-08-9
- US $15.00 / KG
- 98%
- Career Henan Chemical Co