Formoterol
- CAS No.
- 73573-87-2
- Chemical Name:
- Formoterol
- Synonyms
- FORMOTEROL TARTRATE;Oxis;FORMOTEROL;Formoteral;Eformoterol;FormoterolBase;1-nitrotridec-1-ene;Formoterol Standard;FORMOTEROL TARTARATE;Formoterol USP/EP/BP
- CBNumber:
- CB7722411
- Molecular Formula:
- C19H24N2O4
- Molecular Weight:
- 344.4
- MDL Number:
- MFCD05662345
- MOL File:
- 73573-87-2.mol
Boiling point | 603.2±55.0 °C(Predicted) |
---|---|
Density | 1.233±0.06 g/cm3(Predicted) |
solubility | DMSO: 20 mg/mL, soluble |
form | solid |
pka | 8.95±0.50(Predicted) |
color | off-white |
Stability | Stable. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 73573-87-2(CAS DataBase Reference) |
FDA UNII | 5ZZ84GCW8B |
ATC code | R03AC13 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS08 |
---|---|
Signal word | Warning |
Hazard statements | H362-H361 |
Precautionary statements | P201-P260-P263-P264-P270-P308+P313-P201-P202-P281-P308+P313-P405-P501 |
WGK Germany | 3 |
Formoterol price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Medical Isotopes, Inc. | CD33990 | Formoterol-13C-d3 | 73573-87-2 | 1mg | $660 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CHM0034798 | FORMOTEROL TARTRATE 95.00% | 73573-87-2 | 100MG | $885.31 | 2021-12-16 | Buy |
AvaChem | 2256B | Formoterol | 73573-87-2 | 1g | $980 | 2021-12-16 | Buy |
AvaChem | 2256B | Formoterol | 73573-87-2 | 100mg | $269 | 2021-12-16 | Buy |
Formoterol Chemical Properties,Uses,Production
Description
Formoterol is a potent bronchoselective β-agonist with long duration of action given by inhalation.
Chemical Properties
solid
Uses
Labeled Formoterol, intended for use as an internal standard for the quantification of Formoterol by GC- or LC-mass spectrometry.
Uses
Formoterol is a useful compound for treating respiratory obstructive diseases.
Definition
ChEBI: A phenylethanoloamine having 4-hydroxy and 3-formamido substituents on the phenyl ring and an N-(4-methoxyphenyl)propan-2-yl substituent.
brand name
Foradil (Novartis).
General Description
Formoterol (Foradil) isalso a lipophilic (log P= 1.6) and long-acting β2-agonist. Ithas 3'-formylamino ( β-directing) and 4 OH groups on onephenyl ring and a lipophilic -directing N-isopropyl-pmethoxyphenylgroup on the nitrogen atom. Its long DOA(12 hours), which is comparable to that of salmeterol, hasbeen suggested to result from its association with the membranelipid bilayer, from which it gradually diffuses to provideprolonged stimulation of β2 receptors and its resistanceto MAO and COMT. Formoterol has a much faster onset ofaction than does salmeterol as result of its lower lipophilicity.Both of these long-acting drugs are used by inhalationand are recommended for maintenance treatment of asthma,usually in conjunction with an inhaled corticosteroid.
Mechanism of action
Formoterol has 3′-formylamino and 4′-hydroxy ring R3 substitution pattern but also an alkoxyphenylethyl lipophilic group R1 on the nitrogen, similar to ritodrine. Although it is less lipophilic (log P = 1.6) than salmeterol, it has a 12-hour duration of action similar to that for salmeterol. It is administered as an inhaled dry powder, because it is unstable to heat and moisture. It is a mixture of (R,R)-(–)- and (S,S)-(+)-stereoisomers, with the (R,R)-isomer having approximately 1,000-fold more affinity for the β2-receptor than the (S,S)-isomer. Because of its high potency and low dose, however, there is no clinical advantage for using (R,R)-formoterol as bronchodilator compared to the racemate. Unlike salmeterol, formoterol has a faster onset of action as a result of its lower lipophilicity. It is also more potent; a 12-μg dose of formoterol has been demonstrated to be equivalent to a 50-μg dose of salmeterol.
Formoterol Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29889 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9827 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
Shanghai Quedan biology science and technology co., ltd | +86-13004146052 | lnzc@quedan.com.cn | China | 1060 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
View Lastest Price from Formoterol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2019-07-06 | N-[2-Hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide
73573-87-2
|
US $1.00 / kg | 1kg | 99% | Customized | Career Henan Chemical Co |
-
- N-[2-Hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide
73573-87-2
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
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