ChemicalBook >> CAS DataBase List >>8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
![8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride Structure](CAS/20200331/GIF/2250025-93-3.gif)
- CAS No.
- 2250025-93-3
- Chemical Name:
- 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
- Synonyms
- Clozapine N-oxide 2HCl;Clozapine N-oxide diHCl;Clozapine N-oxide dihydrochloride;Clozapine N-oxide dihydrochloride salt;8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
- CBNumber:
- CB14902693
- Molecular Formula:
- C18H21Cl3N4O-
- Molecular Weight:
- 415.74454
- MDL Number:
- MFCD31544504
- MOL File:
- 2250025-93-3.mol
Last updated:2024-11-06 15:28:16
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H336 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P301+P310-P321-P330-P304+P340-P312-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25780 | Clozapine N-oxide (hydrochloride) ≥98% | 2250025-93-3 | 5 mg | $55 | 2024-03-01 | Buy |
| Cayman Chemical | 25780 | Clozapine N-oxide (hydrochloride) ≥98% | 2250025-93-3 | 10 mg | $99 | 2024-03-01 | Buy |
| Cayman Chemical | 25780 | Clozapine N-oxide (hydrochloride) ≥98% | 2250025-93-3 | 25 mg | $179 | 2024-03-01 | Buy |
| Cayman Chemical | 25780 | Clozapine N-oxide (hydrochloride) ≥98% | 2250025-93-3 | 50 mg | $330 | 2024-03-01 | Buy |
| Tocris | 6329 | ClozapineN-oxidedihydrochloride ≥99%(HPLC) | 2250025-93-3 | 50 | $531 | 2021-12-16 | Buy |
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride Chemical Properties,Uses,Production
Biological Activity
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and an agonist of human muscarinic designer receptors (DREADDs). It activates the DREADD receptors hM3Dq and hM4Di.
in vitro
Clozapine N-oxide (CNO) can bind to non-DREADD receptors at concentrations required for DREADD activation, and undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic that acts at a variety of pharmacological targets and produces numerous physiological and behavioral effects.
target
Human muscarinic designer receptors (DREADDs)
storage
-20°C
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride Suppliers
Global( 16)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 3651 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2564 | 58 |
View Lastest Price from 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-06 | Clozapine N-oxide dihydrochloride
2250025-93-3
|
US $46.00-187.00 / mg | 98.11% | 10g | TargetMol Chemicals Inc. |
-
- Clozapine N-oxide dihydrochloride
2250025-93-3
- US $46.00-187.00 / mg
- 98.11%
- TargetMol Chemicals Inc.
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
Clozapine N-oxide dihydrochloride
Clozapine N-oxide dihydrochloride salt
Clozapine N-oxide diHCl
Clozapine N-oxide 2HCl
2250025-93-3