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Remdesivir N-2

Remdesivir N-2 Structure
Remdesivir N-2 structure
CAS No.
1191237-80-5
Chemical Name:
Remdesivir N-2
Synonyms
GS-5;Remdesivir-015;remdesivir N-2;NSJ-Remdesivir-RS009;Remdesivir Impurity 7;Remdesivir Intermediate 4;Remdesivir Intermediate 2;Remdesivir Related Compound 7;Remdesivir No. 5 Intermediate;Remdesivir O-desphosphate acetonide
CBNumber:
CB15493006
Molecular Formula:
C15H17N5O4
Molecular Weight:
331.33
MDL Number:
MFCD32693253
MOL File:
1191237-80-5.mol
Last updated:2024-10-23 13:36:13
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Remdesivir N-2 Properties

Density 1.66±0.1 g/cm3(Predicted)
solubility DMSO:55.5(Max Conc. mg/mL);167.51(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);15.09(Max Conc. mM)
PBS (pH 7.2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM)
DMF:12.0(Max Conc. mg/mL);36.22(Max Conc. mM)
form A solid
pka 14.14±0.10(Predicted)
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
0
2 0

Remdesivir N-2 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0131976 RemdesivirO-desphosphateacetonideimpurity 99.88% 1191237-80-5 1mg $230 2021-12-16 Buy
Ambeed A1220957 (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 97% 1191237-80-5 1g $285 2021-12-16 Buy
Ambeed A1220957 (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 97% 1191237-80-5 5g $1048 2021-12-16 Buy
Ambeed A1220957 (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 97% 1191237-80-5 100mg $80 2021-12-16 Buy
Ambeed A1220957 (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile 97% 1191237-80-5 250mg $115 2021-12-16 Buy
Product number Packaging Price Buy
CS-0131976 1mg $230 Buy
A1220957 1g $285 Buy
A1220957 5g $1048 Buy
A1220957 100mg $80 Buy
A1220957 250mg $115 Buy

Remdesivir N-2 Chemical Properties,Uses,Production

Uses

Remdesivir N-2 can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in the research and development and chemical production of Remdesivir.

Synthesis

Synthesis_1191237-80-5
5.62g of compound GS-441524 was dissolved in 30mL of acetone, 11.50mL of 2,2-dimethoxypropane and 1.34mL of sulfuric acid were added, stirred at 45??C for half an hour, cooled to 25??C, and the organic solvent was removed by rotary evaporation. It was extracted with 100 mL of ethyl acetate and 100 mL of saturated sodium bicarbonate aqueous solution, and the extraction was repeated three times. The ethyl acetate layers were combined, dried by adding anhydrous sodium sulfate, and filtered to remove sodium sulfate. The organic solvent was removed by rotary evaporation, and column chromatography was performed (eluent: petroleum ether/ethyl acetate (V/V)=1/2) to obtain 6.20 g of compound 5 (white solid, 97% yield).

Remdesivir N-2 synthesis

1191237-69-0
77-76-9
1191237-80-5
Synthesis of Remdesivir N-2 from GS-441524 and 2,2-Dimethoxypropane

Remdesivir N-2 Preparation Products And Raw materials

Raw materials

GS-441524 D-Ribofuranose, 1-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,3,5-tris-O-(phenylmethyl)- (3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile Remdesivir impurity2 2,3,5-TRI-O-BENZYL-L-ARABINOFURANOSE
7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE 2,2-Dimethoxypropane

1of2

Preparation Products

Remdesivir

Remdesivir N-2 Suppliers

Global( 102)Suppliers
Supplier Tel Email Country ProdList Advantage
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Chengdu Feibo Pharm Technology Co., Ltd 		+86 028-84641798 15982321820 abby@arkpharm.com China 10924 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-15536356810 1022@dideu.com China 3882 58
Nantong Haigine Pharma Technology Co., Ltd 		0086-513-86266699 CHINA 156 58
Echemi Group 		86-18905328650 18905328650 pharma@echemi.com CHINA 215 58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		21-38751876 +8615000076078 info@rochipharma.com China 431 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Hong Kong Tiansheng New Material Trading Co., Ltd 		+8617320695765 zxx@hktiansheng.com China 973 58
Supplier Advantage
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Chengdu Feibo Pharm Technology Co., Ltd 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Nantong Haigine Pharma Technology Co., Ltd 		58
Echemi Group 		58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Hong Kong Tiansheng New Material Trading Co., Ltd 		58

View Lastest Price from Remdesivir N-2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Remdesivir O-desphosphate acetonide impurity pictures 2024-10-24 Remdesivir O-desphosphate acetonide impurity
1191237-80-5
 US $0.00 / mg 10g TargetMol Chemicals Inc.
Remdesivir N-2 pictures 2023-09-11 Remdesivir N-2
1191237-80-5
 US $80.00 / kg 1kg 99% 10000tons Anhui Ruihan Technology Co., Ltd
Remdesivir O-desphosphate acetonide impurity pictures 2022-02-25 Remdesivir O-desphosphate acetonide impurity
1191237-80-5
 US $5.80 / KG 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
  • Remdesivir N-2 pictures
  • Remdesivir N-2
    1191237-80-5
  • US $80.00 / kg
  • 99%
  • Anhui Ruihan Technology Co., Ltd

1191237-80-5(Remdesivir N-2)Related Search:

2-ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate Remdesivir Remdesivir impurity2 N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester Remdesivir-003-S
(3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir Intermediate 4 Remdesivir Related Compound 7 Remdesivir-015 Remdesivir O-desphosphate acetonide impurity (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile (3Ar,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir No. 5 Intermediate (3αR,4R,6R,6αR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydr NSJ-Remdesivir-RS009 (3ar, 4R, 6R, 6aR) - 4 - (4-aminopyrrole [1,2-f] [1,2,4] triazine-7-yl) - 6 - (hydroxymethyl) - 2,2-dimethyl-tetrahydrofuran [3,4-d] [1,3] dioxazole-4-nitrile 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE-D-ALTRONONITRILE 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)-D-Altrononitrile D-ALTRONONITRILE, 2-C-(4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZIN-7-YL)-2,5-ANHYDRO-3,4-O-(1-METHYLETHYLIDE (3aR,4R,6R,6aR)-4-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile (4R)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile Remdesivir Impurity 7 remdesivir N-2 GS-5 D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- D-Altrononitrile,2-C-(4-aminopyrrolo[2,1-f][1,2,4Chemicalbook]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- Remdesivir Intermediate 2 Remdesivir Acetonide Nitrile Impurity Remdesivir Impurity 7 (Remdesivir Acetonide Nitrile Impurity) Remdesivir O-desphosphate acetonide 1191237-80-5 PEG