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MMP-9-IN-1

MMP-9-IN-1 Structure
MMP-9-IN-1 structure
CAS No.
502887-71-0
Chemical Name:
MMP-9-IN-1
Synonyms
OUN87710;MMP-9-IN-1;OUN87710,MMP-9-IN-1;MMP-9-IN-1, 10 mM in DMSO;N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide;Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-;PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin
CBNumber:
CB15821461
Molecular Formula:
C16H17F2N3O3S
Molecular Weight:
369.39
MDL Number:
MFCD09276885
MOL File:
502887-71-0.mol
Last updated:2025-01-27 09:38:02
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MMP-9-IN-1 Properties

Density 1.37±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO: 125 mg/mL (338.40 mM)
pka 7.80±0.50(Predicted)
form Solid
color White to off-white
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

MMP-9-IN-1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0110110 MMP-9-IN-1 99.74% 502887-71-0 5mg $350 2021-12-16 Buy
ChemScene CS-0110110 MMP-9-IN-1 99.74% 502887-71-0 10mg $550 2021-12-16 Buy
ChemScene CS-0110110 MMP-9-IN-1 99.74% 502887-71-0 50mg $1650 2021-12-16 Buy
ChemScene CS-0110110 MMP-9-IN-1 99.74% 502887-71-0 100mg $2250 2021-12-16 Buy
DC Chemicals 012834 MMP-9-IN-1 502887-71-0 001 $750 2021-12-16 Buy
Product number Packaging Price Buy
CS-0110110 5mg $350 Buy
CS-0110110 10mg $550 Buy
CS-0110110 50mg $1650 Buy
CS-0110110 100mg $2250 Buy
012834 001 $750 Buy

MMP-9-IN-1 Chemical Properties,Uses,Production

Definition

ChEBI: MMP-9-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of [(4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetic acid with the amino group of 4-(difluoromethoxy)aniline. It is a specific matrix metalloproteinase-9 (MMP-9) inhibitor. It has a role as an EC 3.4.24.35 (gelatinase B) inhibitor and an antineoplastic agent. It is an organofluorine compound, an aromatic compound, a pyrimidone, an organic sulfide and a secondary carboxamide.

Biological Activity

MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the heme (PEX) domain of MMP-9 with a Kd of 2.1 μM.

in vivo

MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
MMP-9-IN-1 inhibits cancer cell metastasis in vivo.

Animal Model: 4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor
Dosage: 20 mg/kg
Administration: Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks,
Result: Resulted in a profound delay in tumor growth.
Inhibited cancer cell metastasis.

target

TargetValue
MMP-9
(Cell-free assay)		 2.1 μM(Kd)

MMP-9-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

MMP-9-IN-1 Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7787 56
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4573 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 5944 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 7312 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Lollane Biological Technology Co.,Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58

View Lastest Price from MMP-9-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MMP-9-IN-1 pictures 2024-11-19 MMP-9-IN-1
502887-71-0
 US $97.00-239.00 / mg 99.75% 10g TargetMol Chemicals Inc.
  • MMP-9-IN-1 pictures
  • MMP-9-IN-1
    502887-71-0
  • US $97.00-239.00 / mg
  • 99.75%
  • TargetMol Chemicals Inc.
MMP-9-IN-1 OUN87710 Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]- OUN87710,MMP-9-IN-1 N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin MMP-9-IN-1, 10 mM in DMSO 502887-71-0 API