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| | MMP-9-IN-1 Basic information |
| Product Name: | MMP-9-IN-1 | | Synonyms: | MMP-9-IN-1;OUN87710;Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-;OUN87710,MMP-9-IN-1;N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide;PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin | | CAS: | 502887-71-0 | | MF: | C16H17F2N3O3S | | MW: | 369.39 | | EINECS: | | | Product Categories: | API | | Mol File: | 502887-71-0.mol |  |
| | MMP-9-IN-1 Chemical Properties |
| density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO: 125 mg/mL (338.40 mM) | | pka | 7.80±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | MMP-9-IN-1 Usage And Synthesis |
| Definition | ChEBI: MMP-9-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of [(4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetic acid with the amino group of 4-(difluoromethoxy)aniline. It is a specific matrix metalloproteinase-9 (MMP-9) inhibitor. It has a role as an EC 3.4.24.35 (gelatinase B) inhibitor and an antineoplastic agent. It is an organofluorine compound, an aromatic compound, a pyrimidone, an organic sulfide and a secondary carboxamide. | | Biological Activity | MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the heme (PEX) domain of MMP-9 with a Kd of 2.1 μM. | | in vivo | MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
MMP-9-IN-1 inhibits cancer cell metastasis in vivo. | Animal Model: | 4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor | | Dosage: | 20 mg/kg | | Administration: | Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks, | | Result: | Resulted in a profound delay in tumor growth.
Inhibited cancer cell metastasis. | | | target | | Target | Value | MMP-9
(Cell-free assay) | 2.1 μM(Kd) |
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| | MMP-9-IN-1 Preparation Products And Raw materials |
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