MMP-9-IN-1
| 中文名称 | MMP-9-IN-1 |
|---|---|
| 中文同义词 | 化合物MMP-9-IN-1;N-(4-(二氟甲氧基)苯基)-2-((6-氧代-4-丙基-1,6-二氢嘧啶-2-基)硫代)乙酰胺 |
| 英文名称 | MMP-9-IN-1 |
| 英文同义词 | MMP-9-IN-1;OUN87710;Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-;OUN87710,MMP-9-IN-1;N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide;PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin |
| CAS号 | 502887-71-0 |
| 分子式 | C16H17F2N3O3S |
| 分子量 | 369.39 |
| EINECS号 | |
| 相关类别 | API |
| Mol文件 | 502887-71-0.mol |
| 结构式 |  |
MMP-9-IN-1 性质
| 密度 | 1.37±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | 二甲基亚砜：125 mg/mL（338.40 mM） |
| 酸度系数(pKa) | 7.80±0.50(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
MMP-9-IN-1 (OUN87710)是一种 matrix metalloproteinase-9 (MMP-9) 的特异性抑制剂。MMP-9-IN-1 可选择性地靶向MMP-9的血红素(PEX)域，Kd值为2.1 μM。
| Target | Value |
|
MMP-9
(Cell-free assay) | 2.1 μM(Kd) |
MMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity.
MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells.
Cell Cytotoxicity Assay
| Cell Line: | COS-1 monkey epithelial cell lines |
| Concentration: | 100 μM |
| Incubation Time: | 24 hours |
| Result: | Treatment did not cause notable cytotoxicity. |
Cell Proliferation Assay
| Cell Line: | HT-1080 and MDA-MB-435 cancer cells expressing endogenous MMP-9 |
| Concentration: | 10 μM |
| Incubation Time: | 9 days |
| Result: | Significant inhibition of cell proliferation. |
MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
MMP-9-IN-1 inhibits cancer cell metastasis in vivo.
| Animal Model: | 4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks, |
| Result: |
Resulted in a profound delay in tumor growth.
Inhibited cancer cell metastasis. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-135232 | MMP-9-IN-1 MMP-9-IN-1 | 502887-71-0 | 5mg | 2900元 |
| 2024/04/30 | S0769 | MMP-9-IN-1 MMP-9-IN-1 | 502887-71-0 | 5mg | 2970元 |