ChemicalBook >> CAS DataBase List >>AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
- CAS No.
- 148451-96-1
- Chemical Name:
- AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
- Synonyms
- L732138;L-732,138;L-732138, 10 mM in DMSO;AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER;N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be;3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan;N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROM ETHYL)BENZ;3,5-Bis(trifluoromethyl)benzyl acetyl-L-tryptophanate;N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROMETHYL)-BENZYL ESTER;N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester,L-732,138
- CBNumber:
- CB1721780
- Molecular Formula:
- C22H18F6N2O3
- Molecular Weight:
- 472.38
- MDL Number:
- MFCD00237267
- MOL File:
- 148451-96-1.mol
Last updated:2025-04-17 18:22:24
| Melting point | 147-148 °C(lit.) |
|---|---|
| Boiling point | 554.1±50.0 °C(Predicted) |
| Density | 1.396±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble to 100 mM in ethanol and to 100 mM in DMSO |
| pka | 14.63±0.46(Predicted) |
| form | powder |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 0868 | L-732,138 ≥98%(HPLC) | 148451-96-1 | 10 | $95 | 2021-12-16 | Buy |
| Tocris | 0868 | L-732,138 ≥98%(HPLC) | 148451-96-1 | 50 | $382 | 2021-12-16 | Buy |
| TRC | L730980 | L-732,138 | 148451-96-1 | 100mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB100988 | [3,5-Bis(Trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-Indol-3-Yl)propanoate | 148451-96-1 | 10mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-0021036 | L-732138 99.43% | 148451-96-1 | 1mg | $85 | 2021-12-16 | Buy |
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER Chemical Properties,Uses,Production
Uses
L-732,138 is a Substance P (SP) receptor antagonist.
Biological Activity
Potent and highly selective competitive tachykinin NK 1 receptor antagonist (IC 50 = 2.3 nM).
in vivo
L-732138 (10-4-10-2 mol/kg; intravenous injection; for 15 minutes; male Dunkin-Hartley guinea-pigs) treatment abolishes vagally-induced plasma exudation and significantly inhibits the enhancement by LPS. The LPS-enhanced vagally-induced plasma exudation is not completely inhibited by either L-732138 or SOD pretreatment alone, but is blocked by the combination of both pretreatments[3].
| Animal Model: | Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)[3] |
| Dosage: | 10-4 mol/kg , 10-3 mol/kg and 10-2 mol/kg |
| Administration: | Intravenous injection; for 15 minutes |
| Result: | Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues. |
IC 50
NK1: 2.3 nM (IC50)
storage
Store at RT
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER Suppliers
Global( 60)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 | |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4720 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
View Lastest Price from AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER manufacturers
148451-96-1(AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER)Related Search:
N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROMETHYL)-BENZYL ESTER
L-732,138
AC-TRP-3,5-BIS(TRIFLUOROMETHYL)BENZYL ESTER
N-acetyl-L-tryptophan 3,5-bis*(trifluoromethyl)be
L732138
N-ACETYL-L-TRYPTOPHAN 3,5-BIS(TRIFLUOROM ETHYL)BENZ
3,5-bis(trifluoromethyl)benzyl N-acetyltryptophan
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester,L-732,138
[3,5-Bis(Trifluoromethyl)phenyl]methyl (2S)-2-acetamido-3-(1H-Indol-3-Yl)propanoate
L-Tryptophan, N-acetyl-, [3,5-bis(trifluoromethyl)phenyl]methyl ester
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester >=99% (TLC), powder
3,5-Bis(trifluoromethyl)benzyl acetyl-L-tryptophanate
cytotoxicity,vagally-induced,NK receptor,Neurokinin Receptor,Inhibitor,ntravenously,lipopolysaccharide,plasma,Tachykinin receptor,stimulation,L732138,mitogen,peralgesia,inhibit,L-732138,Antitumorhy,apoptotic,L 732138
L-732138, 10 mM in DMSO
148451-96-1
C22H18F6N2O3
Amino Acids and Peptides
BioChemical
Biochemicals and Reagents
Antagonist
Tachykinins
Peptides