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TRIFLUPROMAZINE HYDROCHLORIDE

CAS No.
1098-60-8
Chemical Name:
TRIFLUPROMAZINE HYDROCHLORIDE
Synonyms
Neoprin;Flumazin;Fluorofen;triflupromazineHCl;LABOTEST-BB LT00772332;TRIFLUPROMAZINE HCL IP/USP;Fluopromazine hydrochloride;TRIFLUPROMAZINE HYDROCHLORIDE;trifluopromazinehydrochloride;Triupromazine Hydrochloride (200 mg)
CBNumber:
CB1723214
Molecular Formula:
C18H20ClF3N2S
Molecular Weight:
388.88
MDL Number:
MFCD00058103
MOL File:
1098-60-8.mol
MSDS File:
SDS
Last updated:2024-11-19 20:33:22

TRIFLUPROMAZINE HYDROCHLORIDE Properties

Melting point 174.0 to 179.0 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
Water Solubility Soluble in water
solubility DMF: 5mg/mL; DMSO: 3mg/mL; Ethanol: 5mg/mL; Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL
color White to Light yellow
λmax 305nm(H2O)(lit.)
Merck 14,9685
BRN 3801519
Stability Hygroscopic
CAS DataBase Reference 1098-60-8
FDA UNII 9E75N4A5HM

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H312+H332
Precautionary statements  P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P312
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  SO8925000
HazardClass  6.1
PackingGroup  III
HS Code  2934302300
NFPA 704
0
3 0

TRIFLUPROMAZINE HYDROCHLORIDE price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1686003 Triflupromazine hydrochloride United States Pharmacopeia (USP) Reference Standard 1098-60-8 200mg $267 2024-03-01 Buy
Sigma-Aldrich 46976 Triflupromazine hydrochloride VETRANAL?, analytical standard 1098-60-8 50mg $190 2022-05-15 Buy
TCI Chemical T3389 Triflupromazine Hydrochloride >98.0%(HPLC)(N) 1098-60-8 5g $122 2024-03-01 Buy
TCI Chemical T3389 Triflupromazine Hydrochloride >98.0%(HPLC)(N) 1098-60-8 25g $365 2024-03-01 Buy
Cayman Chemical 27610 Triflupromazine (hydrochloride) 1098-60-8 1g $32 2024-03-01 Buy
Product number Packaging Price Buy
1686003 200mg $267 Buy
46976 50mg $190 Buy
T3389 5g $122 Buy
T3389 25g $365 Buy
27610 1g $32 Buy

TRIFLUPROMAZINE HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Triflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal. Formulations containing triflupromazine were previously used as antipsychotics.

Originator

Vesprin,Squibb,US,1957

Uses

analgesic, antiinflammatory, antipyretic, COX-II inhibitor

Manufacturing Process

Approximately 3.8 grams of sodamide is freshly prepared from 2.25 grams of sodium, 90 grams of liquid ammonia and a catalytic trace of ferric nitrate. The ammonia is allowed to evaporate. A solution of 19.1 grams of 2-trifluoromethylphenothiazine (prepared by the Bernthsen thionation of 3- trifluoromethyldiphenylamine) in 160 ml of dry benzene is added to the reaction flask followed by 18 grams of 3-chloro-1-dimethylaminopropane. The reaction mixture is heated at reflux for 20 hours. After washing the cooled mixture with 130 ml of water, the organic layer is extracted with several portions of dilute hydrochloric acid. The acid extracts are combined and neutralized with ammonium hydroxide solution. The oily free base is extracted into benzene and purified by distillation to give 19.6 grams of 10-(3'- dimethylaminopropyl)-2-trifluoromethylphenothiazine, boiling point 177° to 181°C at 1 mm. The free base (7 grams) is converted to the hydrochloride salt by reacting an alcoholic solution of the base with hydrogen chloride gas.
Evaporation of the volatiles in vacuo leaves an amorphous solid which is recrystallized from ethanol/ether to pink crystals, MP 173° to 174°C, the hydrochloride salt of the free base prepared above.

brand name

Vesprin (Bristol-Myers Squibb).

Therapeutic Function

Tranquilizer

General Description

Triflupromazinehydrochloride, 10-[3-(dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine monohydrochloride (Vesprin), has agreater milligram potency as an antipsychotic, higher EPS,but lower sedative and hypotensive effects than chlorpromazine.The 2-CF3 versus the 2-Cl is associated with thesechanges. Overall, the drug has uses analogous to those ofchlorpromazine.

TRIFLUPROMAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Suzhou ARTK Medchem Co., Ltd.
+86-512-68323658 +86-18168183658 sales1@artkmedchem.com China 39004 58
TargetMol Chemicals Inc.
+8613564774135 zijue.cai@tsbiochem.com United States 19885 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580 cooperation@kean-chem.com China 40066 58

View Lastest Price from TRIFLUPROMAZINE HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Triflupromazine hydrochloride pictures 2024-11-19 Triflupromazine hydrochloride
1098-60-8
US $33.00-50.00 / mg 99.73% 10g TargetMol Chemicals Inc.
Triflupromazine hydrochloride pictures 2024-11-19 Triflupromazine hydrochloride
1098-60-8
US $33.00-50.00 / mg 99.73% 10g TargetMol Chemicals Inc.
TRIFLUPROMAZINE HYDROCHLORIDE USP/EP/BP pictures 2021-07-24 TRIFLUPROMAZINE HYDROCHLORIDE USP/EP/BP
1098-60-8
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited

TRIFLUPROMAZINE HYDROCHLORIDE Spectrum

10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-phenothiazinmonohydrochlo 10-(3-dimethylaminopropyl)-2-(trifluoromethyl)phenothiazinehydrochloride n,n-dimethyl-2-(trifluoromethyl)-10h-phenothiazine-10-propanaminmonohydr trifluopromazinehydrochloride TRIFLUPROMAZINE HYDROCHLORIDE LABOTEST-BB LT00772332 2-(Trifluoromethyl)-10-[3-(dimethylamino)propyl]-10H-phenothiazine·hydrochloric acid Triflupromazine Hydrochloride (200 mg) Triupromazine Hydrochloride (200 mg) 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride TRIFLUPROMAZINE HYDROCHLORIDE VETRANAL, triflupromazineHCl 10H-Phenothiazine-10-propanamine,N,N-dimethyl-2-(trifluoromethyl)-, hydrochloride (1:1) N,N-Dimethyl-3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propan-1-amine hydrochloride Flumazin Fluopromazine hydrochloride Fluorofen Neoprin 10-[3-(Dimethylamino)-1-propyl]-2-(trifluoromethyl)phenothiazine Hydrochloride TRIFLUPROMAZINE HYDROCHLORIDE USP/EP/BP Triflupromazine Hydrochloride (1686003) TRIFLUPROMAZINE HCL IP/USP Triflupromazine hydrochloride in methanol 1098-60-8 C18H19F3N2SHCl C18H20ClF3N2S C18H19F3N2SClH Antibiotics Chemical Structure OthersAlphabetic TP - TZ Antagonists Dopaminergics Neurotransmitters EQIOXX