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OXITROPIUM BROMIDE

OXITROPIUM BROMIDE Structure
OXITROPIUM BROMIDE structure
CAS No.
30286-75-0
Chemical Name:
OXITROPIUM BROMIDE
Synonyms
Ba 253;ba253br;Oxivent;Ventilat;Tersigan;tersigat;oxitropium;ba-253-br-l;Oxitropiumbromid;oxitropiobromuro
CBNumber:
CB1727939
Molecular Formula:
C19H26BrNO4
Molecular Weight:
412.32
MDL Number:
MFCD05664584
MOL File:
30286-75-0.mol
Last updated:2024-07-25 20:04:51
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OXITROPIUM BROMIDE Properties

Melting point 203-204° (dec)
alpha D21 -25° (c = 2.0 in water)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Very soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
color Off-White to Pale Yellow
Stability Hygroscopic
FDA UNII SF4NW7NH7C
ATC code R03BB02

SAFETY

Risk and Safety Statements

Toxicity LD50 orl-rat: 2250 mg/kg DRFUD44,117,79

OXITROPIUM BROMIDE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000709 Oxitropium bromide European Pharmacopoeia (EP) Reference Standard 30286-75-0 y0000709 $220 2024-03-01 Buy
TRC O847165 Oxitropium bromide 30286-75-0 10mg $105 2021-12-16 Buy
American Custom Chemicals Corporation API0003715 OXITROPIUM BROMIDE 95.00% 30286-75-0 5MG $503.89 2021-12-16 Buy
Product number Packaging Price Buy
Y0000709 y0000709 $220 Buy
O847165 10mg $105 Buy
API0003715 5MG $503.89 Buy

OXITROPIUM BROMIDE Chemical Properties,Uses,Production

Description

Oxitropium bromide is an analog of the anticholinergics methscopolamine bromide and ipratropium bromide, useful in the treatment of bronchial asthma. Cited advantages include a long duration of action and lack of cardiovascular effects.

Chemical Properties

White or almost white, crystalline powder.

Originator

Boehringer Ingelheim (W. Germany)

Uses

Oxitropium Bromide is an anticholinergic agent.

Uses

Anticholinergic; treatment of reversible airways obstruction.

Manufacturing Process

14.5 g (0.05 mol) of (-)-norscopolamine and 5.4 g (0.05 mol) of ethyl bromide were dissolved in 300 cc of acetonitrile, 5.3 g (0.05 mol) of anhydrous sodium carbonate were suspended in the solution, and the suspension was heated at the boiling point for 10 hours. After a boiling time of 2.5 and 5 hours, respectively, the supply of ethyl bromide and sodium carbonate in the reaction mixture was replenished by adding each time 5.4 g (0.05 mol) of ethyl bromide and 5.3 g (0.05 mol) of anhydrous sodium carbonate. At the end of 10 hours of boiling, the inorganic sodium salts which had separated out were separated by vacuum filtration, the filter cake was washed with acetonitrile, and the acetonitrile was distilled out of the filtrate. The distillation residue was dissolved in ether, the solution was extracted with a small amount of water and then dried, and the ether was distilled off, yielding raw (-)-N-ethylnorscopolamine.
7.0 g (0.022 mol) of (-)-N-ethylnorscopolamine were dissolved in acetonitrile, 10.4 g (0.11 mol) of methyl bromide were added to the solution, and the mixture was allowed to stand at room temperature. The crystalline precipitate formed thereby was collected and recrystallized from acetonitrile.8.9 g (97.8% of theory) of white crystalline (-)-N-ethylnorscopolamine methobromide, melting point 203°C to 204°C (decomposition), were obtained.

brand name

Oxivent (Boehringer Ingelheim);TERSIGAT.

Therapeutic Function

Anticholinergic bronchodilator

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. An anticholinergic bronchodilator. When heated to decomposition it emits very toxic fumes of NOx and Brí.

OXITROPIUM BROMIDE Preparation Products And Raw materials

Raw materials

Sodium carbonate Methyl bromide Bromoethane

Preparation Products

Oxitropium Bromide EP Impurity A

OXITROPIUM BROMIDE Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-18789408387 1057@dideu.com China 3959 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15352 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58
PT CHEM GROUP LIMITED 		+86-85511178; +86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49978 58
Protheragen-ING 		+16313385890 info@protheragen-ing.com United States 3868 58
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 sales@chem-strong.com China 18070 56
BOC Sciences -- info@bocsci.com USA 0 65
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
AFINE CHEMICALS LIMITED 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58
Protheragen-ING 		58
ChemStrong Scientific Co.,Ltd 56
BOC Sciences 65

View Lastest Price from OXITROPIUM BROMIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
OXITROPIUM BROMIDE pictures 2024-07-25 OXITROPIUM BROMIDE
30286-75-0
 US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

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(-)-n-ethyl-norhyoscine-methobromide 3-oxa-9-azoniatricyclo(3.3.1.0(sup2,4))nonane,9-ethyl-7-(3-hydroxy-1-oxo-2-ph ba253br ba-253-br-l bromurodeoxitropio Oxivent Scopolamine ethobromide Tersigan Ventilat Oxitropiumbromid N-Ethylnorscopolammonium bromide OXITROPIUM BROMIDE enylpropoxy)-9-methyl-,bromide,(7(s)-(1-alpha,2-beta,4-beta,5-alpha,7-beta)) n-ethyl-norscopolaminemethobromide oxitropiobromuro oxitropium oxytropiumbromide tersigat 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-ethyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, [7(S)-(1a,2b,4b,5a,7b)]- 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 9-ethyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide, (1a,2b,4b,5a,7b)- (9CI) Ba 253 Hyoscine ethobromide N-Ethylnorscopolamine methylbromide N-Ethylnorscopolamine-methyl bromide N-Ethylscopolammonium bromide (6CI, 7CI) Oxitropium bromide CRS (1R,2R,4S,5S,7s,9R)-9-ethyl-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide 30286-75-0 C19H26NO4Br C19H26BrNO4