4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
- CAS No.
- 30827-99-7
- Chemical Name:
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
- Synonyms
- AEBSF;AEBSF HCL;AEBSF HYDROCHLORIDE;CS-2583;AEBSF HCI;PEFABLOC SC;PEFABLOC(R) SC;AEBSF Solution;PEFABLOC SC PLUS;TIMTEC-BB SBB003219
- CBNumber:
- CB1769137
- Molecular Formula:
- C8H11ClFNO2S
- Molecular Weight:
- 239.69
- MDL Number:
- MFCD00132962
- MOL File:
- 30827-99-7.mol
- MSDS File:
- SDS
| Melting point | 175-177 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.) |
| form | Powder |
| color | White |
| PH | pH3.0～5.0 (10g/L, 25℃) |
| Water Solubility | 10 g/L (20 ºC) |
| Sensitive | Moisture Sensitive |
| BRN | 7604627 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator |
| InChIKey | WRDABNWSWOHGMS-UHFFFAOYSA-N |
| CAS DataBase Reference | 30827-99-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | DHA6VL95HL |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-36/37/38 | |||||||||
| Safety Statements | 45-36/37/39-26-36 | |||||||||
| RIDADR | UN 3261 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29214990 | |||||||||
| NFPA 704 |
|
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 76307 | Pefabloc? SC analytical standard | 30827-99-7 | 100mg | $137 | 2024-03-01 | Buy |
| Sigma-Aldrich | 76307 | Pefabloc? SC analytical standard | 30827-99-7 | 1g | $902 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.32586 | AEBSF,HCl≥99%byHPLC-CAS30827-99-7-Calbiochem | 30827-99-7 | 250mg | $260 | 2024-03-01 | Buy |
| Sigma-Aldrich | 101500 | AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem AEBSF,CAS30827-99-7,isaspecificirreversibleinhibitorofchymotrypsin,kal | 30827-99-7 | 100mg | $130 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.08436 | InSolution AEBSF, Hydrochloride - CAS 30827-99-7 - Calbiochem A 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride in H?O. | 30827-99-7 | 50MG | $135 | 2024-03-01 | Buy |
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Chemical Properties,Uses,Production
Description
AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.
Chemical Properties
white powder
Uses
Recommended concentrations for use are 0.1-1 mM.
Uses
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
General Description
Pefabloc? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.
Biochem/physiol Actions
Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM.
storage
Store at -20°C
References
1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639 2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12834 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18150 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 232 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 193 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1376 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
View Lastest Price from 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | AEBSF hydrochloride
30827-99-7
|
US $43.00-92.00 / mg | 99.61% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-05 | 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
30827-99-7
|
US $0.00-0.00 / KG | 10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-11-05 | 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
30827-99-7
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Weibang Biotechnology Co., Ltd |
-
- AEBSF hydrochloride
30827-99-7
- US $43.00-92.00 / mg
- 99.61%
- TargetMol Chemicals Inc.
-
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
30827-99-7
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
30827-99-7
- US $0.00-0.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
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